... was dramatically increased following CAMSAP3 removal, leading to the upregulation of Akt proteins (also known as protein kinase B proteins, hereafter Akt) activity, which is known to promote EMT. These findings suggest that CAMSAP3 functions to protect lung carcinoma cells against EMT by suppressing Akt activity...

... been understood that Akt activation occurs solely at the plasma membrane. We show that PtdIns(3,4,5) P 3 -dependent in situ activation of Akt can occur in subcellular compartments. Protein kinase B Akt Rapalogue dimerisation Phosphoinositide Subcellular compartment Protein kinase B...

... of fat and muscle cells. Although the activation of the PI3-kinase/protein kinase B (PKB) pathway is central to this effect of insulin, the key substrates for PKB that are involved require identification. Here we report that serine318 on the FYVE domain-containing PtdIns(3) P 5-kinase (PIKfyve...

... growth, cell motility, cell adhesion and cell survival. (e-mail: [email protected] ) © 2001 by Company of Biologists 2001 Phosphoinositide 3-kinase PH domains Rac-1 Protein kinase B Tec kinases The controlled metabolism of inositol phospholipids is fundamental...

... Phagosome fusion Phosphoinositide 3-kinase Protein kinase B Phagocytosis is the process by which particulate matter is internalized into cells (for review see Aderem and Underhill, 1999 ; Allen and Aderem, 1996 ; Brown, 1995 ; Swanson and Baer, 1995 ). It often consists of the engagement...