... trafficking from endoplasmic reticulum to perinuclear compartments, and Ca 2+ -binding ability is crucial for the function of ALG2 in this process. STING ALG2 Innate immune response Protein interaction Vesicle trafficking National Natural Science Foundation of China http://dx.doi.org...

... Kif15 Microtubule Myosin-IIB Protein interaction Rat astrocytes Migration Kinesin-12 (also called Kif15, KSNL7 and HKLP2) is a microtubule-based plus-end-directed motor protein originally studied in the context of its role in mitosis. Recent studies have resolved key aspects...

... © 2013. Published by The Company of Biologists Ltd 2013 Protein interaction Cell polarity Yeast Septin assembly Myosin assembly Septin filaments provide a distinct compartment and scaffold for the contractile actin-myosin ring and other proteins involved in cell division...

... was previously shown to hydroxylate other substrates within a highly conserved protein interaction domain, termed the ankyrin repeat domain (ARD). However, to date, the biological role of FIH-1-dependent ARD hydroxylation could not be clarified for any ARD-containing substrate. The apoptosis-stimulating p53...

... © 2013. Published by The Company of Biologists Ltd 2013 Claudins Occludin Tricellulin MarvelD3 Tight junction Protein interaction Tight junctions (TJs) seal the paracellular cleft of epithelial and endothelial cells most apical of the lateral cell membranes. They separate...

... under constitutive thymidine-kinase promoter (phRL-TK-luc; Promega) as a transfection control for normalisation in DUAL-Luciferase® assays. Protein-protein interactions in PC12 cells and neurons were confirmed using the CheckMate®/Flexi mammalian two-hybrid system (Promega, Southampton, UK). Proteins...

... stabilizes this peptide transporter ( Lehner et al., 1998 ). Moreover, the TMD0 of the sulfonylurea receptor 1 mediates the interaction with the potassium channel Kir6.2 and influences its trafficking and gating ( Chan et al., 2003 ). Notably, the LAMP proteins interact independently with TAPL and both...

...   A. , Müller   J. , Johnsson   N. ( 2012 ). Detecting protein-protein interactions with the Split-Ubiquitin sensor.   Methods Mol. Biol.   786 , 115 – 130 . 10.1007/978-1-61779-292-2_7 Eckert   J. H. , Johnsson   N. ( 2003 ). Pex10p links the ubiquitin conjugating enzyme Pex4p...

...-mediated cellular biological functions. * These authors contributed equally to this work ‡ Author for correspondence ( huzhuowei@imm.ac.cn ) 27 5 2011 © 2011. 2011 TRB3 SMAD3 Protein interaction The transcription factor SMAD3 is a downstream modulator of TGF-β...

... in neurodegeneration, suggesting a novel therapeutic target in neurodegenerative diseases. * Author for correspondence (e-mail: seonghong@chonbuk.ac.kr ) 23 2 2009 © The Company of Biologists Limited 2009 2009 HtrA2 (Omi) Heat-shock protein Oligomeric amyloid-β protein Protein interaction...

..., differentiation and inflammatory processes, as a protein interaction partner of NOD2. We demonstrate a complex influence of the CD147-NOD2 interaction on NOD2-dependent signaling responses. We show that CD147 itself acts as an enhancer of the invasion of Listeria monocytogenes , an intracellular bacterial...

... is redirected from the nucleoplasm to the nucleoli. Thus, we propose that the NoLS may be used as a tool to visualize and prove protein interactions in a cellular context. This new tool aimed at analyzing protein interactions offers the advantage of assessing direct protein interactions in a cellular context...

... ) 14 2 2006 © The Company of Biologists Limited 2006 2006 Ryanodine receptor Snapin SNARE complex Protein interaction Neurosecretion Ionised calcium (Ca 2+ ) is the trigger for synaptic vesicle fusion with the presynaptic membrane and subsequent neurotransmitter release...

...-ubiquitin Signal sequence Protein interaction Saccharomyces cerevisiae * Author for correspondence (e-mail: nils.johnsson@itg.fzk.de ) 24 11 2004 © The Company of Biologists Limited 2005 2005 Protein translocation across the membrane of the endoplasmic reticulum (ER...

... membrane Collagen (IV) Usher syndrome Protein interaction Usher syndrome is the leading genetic disorder of combined hearing and vision loss. The main clinical symptoms are retinitis pigmentosa (RP) and hearing loss. The disorder affects some 3/100,000 people in the general population...

... in the living cells of the yeast Saccharomyces cerevisiae . We found that Pex10p plays a central role in the protein interaction network by connecting the ubiquitin conjugation enzyme Pex4p to the other members of the protein import machinery. A yeast strain harboring a deletion of PEX3 enabled us to estimate...

... domains are defined as multifunctional protein-protein interaction modules that play a central role in organizing diverse cell signaling assemblies ( Fujita and Kurachi, 2000 ; Harris and Lim, 2001 ). To our knowledge, none of SAP97 partners already described has been shown to interact with its PDZ3...

... The Company of Biologists Limited 2001 2001 Endoplasmic reticulum Localization Mannosidase Retrieval Protein interaction Split-ubiquitin The α1,2-mannosidase (Mns1p) involved in glycoprotein biosynthesis in Saccharomyces cerevisiae is a type II transmembrane glycoprotein with a short...