... immune response Protein interaction Vesicle trafficking National Natural Science Foundation of China http://dx.doi.org/10.13039/501100001809 31870730 The innate immune system, the first line of host defense, is critical for a host to combat microbial invasion including by viruses...

... to integrate microtubules and actin filaments in certain regions of cells. In astrocytes, this interaction can modulate their migration. Kinesin-12 Kif15 Microtubule Myosin-IIB Protein interaction Rat astrocytes Migration National Natural Science Foundation of China 10.13039/501100001809...

... ( [email protected] ) 20 05 2013 © 2013. Published by The Company of Biologists Ltd 2013 Protein interaction Cell polarity Yeast Septin assembly Myosin assembly Septin filaments provide a distinct compartment and scaffold for the contractile actin-myosin ring and other...

... was previously shown to hydroxylate other substrates within a highly conserved protein interaction domain, termed the ankyrin repeat domain (ARD). However, to date, the biological role of FIH-1-dependent ARD hydroxylation could not be clarified for any ARD-containing substrate. The apoptosis-stimulating p53...

... © 2013. Published by The Company of Biologists Ltd 2013 Claudins Occludin Tricellulin MarvelD3 Tight junction Protein interaction Tight junctions (TJs) seal the paracellular cleft of epithelial and endothelial cells most apical of the lateral cell membranes. They separate...

... with the proteins of the IKK-complex in situ , we employed proximity ligation assays (PLA). These assays combine antibody-labelling with signal detection by rolling-circle amplification of secondary antibody-linked oligonucleotides and subsequent fluorescent staining, thus indicating protein interactions...

... translocation Protein interaction Subcellular trafficking TMD0 Lysosomes are single-membrane-bound organelles for degradation of endogenous or exogenous macromolecules. Therefore, lysosomes are filled with an armada of different hydrolases that function optimally at acidic pH. Mutations...

... ) 19 4 2012 © 2012. Published by The Company of Biologists Ltd 2012 Constraint interaction networks Cytokinesis Protein interaction Split–Ubiquitin Systems biology To separate mother from daughter, yeast cells undergo a well-orchestrated set of biochemical reactions...

... the carboxyl-terminal tail domain of BMP type II receptor . Mol. Cell. Biol. 27 , 5776 - 5789 . Chen Y. G. , Wang Z. , Ma J. , Zhang L. , Lu Z. ( 2007 ). Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling . J...

... in neurodegeneration, suggesting a novel therapeutic target in neurodegenerative diseases. * Author for correspondence (e-mail: [email protected] ) 23 2 2009 © The Company of Biologists Limited 2009 2009 HtrA2 (Omi) Heat-shock protein Oligomeric amyloid-β protein Protein interaction...

..., differentiation and inflammatory processes, as a protein interaction partner of NOD2. We demonstrate a complex influence of the CD147-NOD2 interaction on NOD2-dependent signaling responses. We show that CD147 itself acts as an enhancer of the invasion of Listeria monocytogenes , an intracellular bacterial...

... is redirected from the nucleoplasm to the nucleoli. Thus, we propose that the NoLS may be used as a tool to visualize and prove protein interactions in a cellular context. References Adachi, Y., Copeland, T. D., Hatanaka, M. and Oroszlan, S. ( 1993 ). Nucleolar targeting signal of Rex protein of human T...

... and controlling it are not known. Recently, presynaptic ryanodine-sensitive Ca 2+ stores have been implicated in spontaneous, as well as depolarisation-induced, exocytosis in the central and peripheral nervous system. Ryanodine receptor Snapin SNARE complex Protein interaction Neurosecretion ©...

... for correspondence (e-mail: [email protected] ) 24 11 2004 © The Company of Biologists Limited 2005 2005 Sec complex Split-ubiquitin Signal sequence Protein interaction Saccharomyces cerevisiae Protein translocation across the membrane of the endoplasmic reticulum (ER...

... proteins, is integrated into basement membranes via specific protein interactions. We employed a fusion peptide approach as a first step towards examining how usherin is integrated into the basement membrane suprastructure. Fig. 2 illustrates the domain structure of the usherin protein, and indicates...

... in the living cells of the yeast Saccharomyces cerevisiae . We found that Pex10p plays a central role in the protein interaction network by connecting the ubiquitin conjugation enzyme Pex4p to the other members of the protein import machinery. A yeast strain harboring a deletion of PEX3 enabled us to estimate...

... as multifunctional protein-protein interaction modules that play a central role in organizing diverse cell signaling assemblies ( Fujita and Kurachi, 2000 ; Harris and Lim, 2001 ). To our knowledge, none of SAP97 partners already described has been shown to interact with its PDZ3 domain. The neuronal G-protein...

... for its Rer1p-dependent ER localization. In order to elucidate the mechanism of Rer1p involvement in ER localization of Mns1p, we applied the split-ubiquitin system to determine whether these proteins interact. Using this method, we demonstrate that both Mns1p and Sec12p interact with Rer1p in vivo...

... primarily to reduce its availability. * Author for correspondence (e-mail: [email protected] ) © 2001 by Company of Biologists 2001 Nuclear structure Nuclear protein Protein interaction Supramolecular regulation PML Sp100 Nuclear bodies described by Bernhard’s group ( de...

... 09 1993 14 10 1993 © 1994 by Company of Biologists 1994 basement membrane protein interaction integrin nidogen fibulin-1 Laminin and collagen IV are the major constituents of basement membranes, where they exist as multiple isoforms with different distributions...