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Keywords: Protein folding
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Journal Articles
Journal Articles
J Cell Sci (2020) 133 (22): jcs251983.
Published: 27 November 2020
... pathway. Endoplasmic reticulum Membrane protein Protein folding Ribosome Translation Eukaryotic cells can expend up to 30% of their energy resources on the production of new proteins ( Buttgereit and Brand, 1995 ). One reason that protein synthesis accounts for such a large proportion...
Journal Articles
J Cell Sci (2020) 133 (21): jcs240366.
Published: 10 November 2020
... or financial interests. © 2020. Published by The Company of Biologists Ltd 2020 Summary: A review of how ERp44 is key in sculpting the composition of the secretome and of the organelles of the early secretory pathway. ERp44 Protein folding Quality control Secretory pathway Zinc...
Journal Articles
J Cell Sci (2020) 133 (8): jcs241976.
Published: 30 April 2020
... sensitivity demonstrates the requirement for a membrane protein to shuttle electrons from the cytosol to the ER. These results provide compelling evidence for the crucial role of the cytosol in regulating ER redox homeostasis, ensuring correct protein folding and facilitating the degradation of misfolded ER...
Journal Articles
J Cell Sci (2020) 133 (8): jcs243519.
Published: 24 April 2020
... responsibilities overseen by client proteins requiring the EMC for maturation. EMC Membrane protein Protein quality control Protein folding The eukaryotic endoplasmic reticulum (ER) houses the machinery responsible for biogenesis of secreted and integral membrane proteins. Insertion, folding...
Journal Articles
J Cell Sci (2020) 133 (3): jcs231340.
Published: 4 February 2020
.... In this SRP-dependent co-translational ER-targeting mode, ribosomes associate with the ER membrane via ER translocon complexes. These membrane protein complexes translocate nascent soluble proteins into the ER, integrate nascent membrane proteins into the ER membrane, mediate protein folding and membrane...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (6): 1180–1192.
Published: 15 March 2015
... for correspondence ( reyhuei@gate.sinica.edu.tw ) Competing interests The authors declare no competing or financial interests. 27 10 2014 15 01 2015 © 2015. Published by The Company of Biologists Ltd 2015 Chaperone Protein folding Protein phosphatase 1 Cdc48 Shp1 Type 1...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2010) 123 (5): 787–794.
Published: 1 March 2010
... a general strategy for both non-secretory and specialized secretory cells. * Present address: MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK ‡ Author for correspondence ( i.braakman@uu.nl ) 3 12 2009 © 2010. 2010 Protein folding Folding stress...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2008) 121 (5): 717–723.
Published: 1 March 2008
... Francisco CA 94158, USA 11 12 2007 © The Company of Biologists Limited 2008 2008 HSP90 Molecular chaperones Protein folding Radicicol Heat shock protein 90 kDa (hereafter termed HSP90) works in an ATP-dependent manner to regulate the activity of a limited subset of medically...
Journal Articles
J Cell Sci (2006) 119 (21): 4373–4380.
Published: 1 November 2006
... chaperones has revealed important new information on the mechanisms regulating protein folding and quality control. Tight regulation of N -glycan modifications is crucial to maintain protein quality control, to ensure the synthesis of functional polypeptides and to avoid constipation of the ER with folding...
Journal Articles
J Cell Sci (2006) 119 (14): 2863–2869.
Published: 15 July 2006
... © The Company of Biologists Limited 2006 2006 Protein associations Protein stability Protein folding Macromolecular crowding Macromolecular confinement Macromolecular adsorption Although the time when a living cell was regarded naively as a `bag of enzymes' is long past...
Journal Articles
J Cell Sci (2006) 119 (4): 615–623.
Published: 15 February 2006
... that ERp57 participates in glycoprotein biogenesis either alone or in tandem with calnexin and calreticulin. e-mail: david.williams@utoronto.ca 22 12 2005 © The Company of Biologists Limited 2006 2006 Calnexin Calreticulin Endoplasmic reticulum Quality control Protein folding...
Journal Articles
Journal Articles
J Cell Sci (2005) 118 (7): 1485–1492.
Published: 1 April 2005
...Zlatka Kostova; Dieter H. Wolf In the endoplasmic reticulum (ER), N -linked glycans (N-glycans) function as signals to recruit the lectin chaperones involved in protein folding, quality control and ER-associated degradation. We undertook a systematic study of the four N-glycans of mutated...
Journal Articles
J Cell Sci (2004) 117 (18): 4055–4066.
Published: 15 August 2004
...Takunari Yoneda; Cristina Benedetti; Fumihiko Urano; Scott G. Clark; Heather P. Harding; David Ron Protein folding in the mitochondria is assisted by nuclear-encoded compartment-specific chaperones but regulation of the expression of their encoding genes is poorly understood. We found...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (15): 3367–3377.
Published: 1 July 2004
... of Geneva, 1211 Geneva 4, Switzerland ‡ Present address: Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK 23 2 2004 © The Company of Biologists Limited 2004 2004 Actin Nemaline myopathy Actin polymerization Protein folding...
Journal Articles
J Cell Sci (2004) 117 (6): 907–918.
Published: 22 February 2004
...Philippe Collin; Pascale B. Beauregard; Aram Elagöz; Luis A. Rokeach Calnexin is a molecular chaperone playing key roles in protein folding and the quality control of this process in the endoplasmic reticulum. We, and others, have previously demonstrated that cnx1 + , the gene encoding...
Journal Articles
J Cell Sci (2002) 115 (21): 3983–3990.
Published: 1 November 2002
...-mail: hepstein@bcm.tmc.edu ) © The Company of Biologists Limited 2002 2002 UCS Myosin chaperone UNC-45 Protein folding Myosins are a large family of protein motors that contain at least 18 different classes. They interact with actin filaments to generate a broad spectrum of eukaryotic cell...