... and the Cdc48 complex is required for its degradation. The C-terminal transmembrane domain of Bqt4 was necessary and sufficient for proteasome-dependent protein degradation. Accumulation of Bqt4 at the INM impaired cell viability with nuclear envelope deformation, suggesting that quantity control of Bqt4 plays...

... of chloroplasts depends on the correct targeting, translocation, assembly and degradation of thousands of different chloroplast proteins. An overview of these diverse proteostatic processes is presented. Chloroplast Plastid Protein degradation Protein import Protein translocation Ubiquitin...

... overcome Hsp70 ablation by increasing misfolded protein degradation. Indeed, RMS13-R cells degraded ERAD substrates more rapidly than RMS cells and induced the autophagy pathway. Surprisingly, inhibition of the proteasome or ERAD had no effect on RMS13-R cell survival, but silencing of select autophagy...

... by The Company of Biologists Ltd 2018 http://www.biologists.com/user-licence-1-1/ Summary: Hsp110 associates with the proteasome and ensures the efficient delivery of Hsp70 chaperone-associated proteins for proteolysis in the yeast S. cerevisiae. Protein degradation Proteasome Ubiquitin...

... Fbxl17 binding. Deacetylation on both K200 and K205 by Sirtuin 1 (Sirt1) and acetylation of p300 (EP300) on K205 collaboratively prepare the motif for SCF Fbxl17 binding thereby triggering PRMT1 protein degradation. Pathogen-derived lipopolysaccharide (LPS) downregulates Sirt1 and p300 to protect PRMT1...

... polypeptides to escape proteasomal degradation and/or selectively modulates substrate degradation. Bag6 Mislocalised proteins Proteasomes Protein degradation TPR Ubiquitylation The ubiquitin-proteasome system (UPS) constitutes a main pathway for protein degradation in eukaryotic cells...

... Authors for correspondence ( [email protected] ; [email protected] ) Competing interests The authors declare no competing or financial interests. 10 12 2014 16 3 2015 © 2015. Published by The Company of Biologists Ltd 2015 Tubulin Protein degradation Chaperone...

... unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Aggresomes BAG6 Mislocalised membrane proteins Polyubiquitylation Protein degradation Small glutamine-rich tetratricopeptide repeat-containing protein alpha Hydrophobic amino...

... environment containing specific proteins. The mechanisms of integral INM protein degradation are unknown. Here, we investigated the turnover of Asi2, an integral INM protein in Saccharomyces cerevisiae . We report that Asi2 is degraded by the proteasome independently of the vacuole and that it exhibited...

... Protein degradation Proteolytic cleavage Chaperone-mediated autophagy TDP-43-positive aggregate TDP-43 proteinopathies TAR DNA-binding protein (TDP-43, also known as TARDBP) is an RNA- and DNA-binding factor with multiple cellular functions ( Baloh, 2011 ; Buratt et al., 2001; Chen-Plotkin et...

... of Biologists Ltd 2012 Arsenic toxicity Protein aggregation Protein degradation Protein folding Yeast References Aguzzi   A. , Rajendran   L. ( 2009 ). The transcellular spread of cytosolic amyloids, prions, and prionoids.   Neuron   64 , 783 – 790 . 10.1016/j.neuron.2009.12.016...

... earlier work demonstrated the possible regulation of the Notch1–RBP-Jk pathway through protein degradation of RBP-Jk; however, the potential regulator for the degradation of RBP-Jk remains to be determined. Here, we report that the expression of endogenous and exogenous RBP-Jk was increased significantly...

... linkages . J. Biol. Chem. 282 , 17375 - 17386 . Kim H. T. , Kim K. P. , Uchiki T. , Gygi S. P. , Goldberg A. L. ( 2009 ). S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains . EMBO J. 28 , 1867 - 1877 . Kim Y...

... activity by the dissociation of the Notch1-IC–RBP-Jk complex after processing by γ-secretase. Notch1-IC is capable of forming a trimeric complex with Fbw7 and AICD, and AICD enhances the protein degradation of Notch1-IC through an Fbw7-dependent proteasomal pathway. AICD downregulates the levels of RBP-Jk...

...-deficient cells than in SGK1 wild-type cells. Notch1-IC was able to form a trimeric complex with Fbw7 and SGK1, thereby SGK1 enhanced the protein degradation of Notch1-IC via a Fbw7-dependent proteasomal pathway. Furthermore, activated SGK1 phosphorylated Fbw7 at serine 227, an effect inducing Notch1-IC...

... protein degradation TPX2 The Aurora-A kinase (officially known as Serine/threonine-protein kinase 6) is an important regulator of cell division and acts in several aspects of spindle formation and function (for reviews, see Barr and Gergely, 2007 ; Vader and Lens, 2008 ). The levels of Aurora...

.... and Szekely, L. ( 2001 ). Proteins associated with the promyelocytic leukemia gene product (PML)-containing nuclear body move to the nucleolus upon inhibition of proteasome-dependent protein degradation. Proc. Natl. Acad. Sci. USA 98 , 1012 -1017. Nijman, S. M., Luna-Vargas, M. P., Velds...

... Neurodegeneration Alzheimer's disease Protein aggregation Protein degradation As the UPS is important for maintaining intracellular homeostasis, it is not surprising that impairment of the UPS has been observed to occur in the pathogenesis of numerous diseases, often demonstrated by the accumulation...

...-proteasome pathway Protein degradation Yeast Toxic metals are ubiquitously present in nature and all organisms have developed mechanisms to evade toxicity and to acquire tolerance. These mechanisms include increased metal export from the cell, sequestration within internal organelles, chelation...

...-Sem1 as immunogen. ‡ Author for correspondence (e-mail: [email protected] ) * Authors contributed equally 1 10 2004 © The Company of Biologists Limited 2004 2004 Protein degradation Dsk2 Ubiquitin receptor Sem1 Rpn10 Proteasome stability...