... 29 2 2016 © 2016. Published by The Company of Biologists Ltd 2016 Summary: Rab8 can induce Rac1- and Tiam1-dependent cortical actin polymerization and focal adhesion disassembly through the proteases MT1-MMP and calpain, and Rho-GTPase-dependent mechanisms. Actin Cytoskeleton...

... ; [email protected] ; [email protected] ) 28 5 2011 © 2011. 2011 Brain Extracellular matrix Plasticity Proteases MMP-9 It has been clearly established that experience modifies functional circuits in the brain ( Chklovskii et al., 2004 ). Furthermore, it has been...

..., the presence of reactive oxygen species and the difficulties associated with assembly of the electron transport chain, which consists of components encoded by both the mitochondrial and the nuclear genomes. Mitochondria have dedicated molecular chaperones and proteases that promote proper protein folding...

... to the membrane when CMA is activated is altered in lysosomes from old animals, leading to the presence of an unstable pool of lumenal LAMP-2A. By contrast, the regulated cleavage of LAMP-2A at the lysosomal membrane is reduced owing to altered association of the receptor and the protease responsible for its...

... Caveolin-1 Proteases Proteolysis Invasion Extracellular matrix (ECM) degradation by proteases occurs at many stages of malignant progression, including local invasion, angiogenesis and intravasation and extravasation of tumors during metastasis ( Liotta et al., 1983 ; McCawley and Matrisian...

...Sean P. Flaherty; Nicholas J. Swann ABSTRACT The guinea pig sperm acrosome reaction is characterized by a complex temporal and structural pattern of membrane fusions. In this study, we have used specific protease inhibitors to determine if proteases regulate this pattern of membrane fusions during...

...E. Cohen; I. Ophir; Y. I. Henis; A. Bacher; Y. Ben Shaul ABSTRACT In the human colon adenocarcinoma cell line HT29, tight junctions can be induced by treatment with appropriate proteases or salt solutions. The temperature dependence of induced tight junction formation is characterized by a marked...