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Keywords: Protamine
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Journal Articles
J Cell Sci (2021) 134 (7): jcs258391.
Published: 15 April 2021
... and male sterility. Immunofluorescence and fluorescent in situ hybridization revealed that Ipo9 KO mutants display chromosome condensation and segregation defects during meiosis. In addition, Ipo9 KO mutant males form abnormally structured sperm and fail to properly exchange histones for protamines. Ipo9...
Includes: Supplementary data
Journal Articles
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Imaging
J Cell Sci (2017) 130 (17): 2854–2866.
Published: 1 September 2017
... and the protamine PRM2 due to translational derepression. The aberrant localisation of these key sperm-specific chromatin components, together with the persistence of somatic histones, results in abnormal spermatid elongation, failure to complete spermatid differentiation and azoospermia in these mice. Our study...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (10): 1835–1844.
Published: 15 May 2017
... (also known as H2AFX) phosphorylation at Ser139 (γH2AX), and replacement of histones by protamines. Previously, we have reported that the spermatid protein kinase TSSK6 is essential for fertility in mice, but its specific role in spermiogenesis is unknown. Here, we show that TSSK6 expression...
Includes: Supplementary data
Journal Articles
Journal Articles