... and male sterility. Immunofluorescence and fluorescent in situ hybridization revealed that Ipo9 KO mutants display chromosome condensation and segregation defects during meiosis. In addition, Ipo9 KO mutant males form abnormally structured sperm and fail to properly exchange histones for protamines. Ipo9...

... and the protamine PRM2 due to translational derepression. The aberrant localisation of these key sperm-specific chromatin components, together with the persistence of somatic histones, results in abnormal spermatid elongation, failure to complete spermatid differentiation and azoospermia in these mice. Our study...

... (also known as H2AFX) phosphorylation at Ser139 (γH2AX), and replacement of histones by protamines. Previously, we have reported that the spermatid protein kinase TSSK6 is essential for fertility in mice, but its specific role in spermiogenesis is unknown. Here, we show that TSSK6 expression...

...Christina Rathke; Willy M. Baarends; Sunil Jayaramaiah-Raja; Marek Bartkuhn; Rainer Renkawitz; Renate Renkawitz-Pohl In higher organisms, the chromatin of sperm is organised in a highly condensed protamine-based structure. In pre-meiotic stages and shortly after meiosis, histones carry multiple...

...Carlos R. Morales; Yunhee K. Kwon; Norman B. Hecht ABSTRACT During spermatogenesis in mammals, the transcripts of transition protein 1 (TP 1) and protamine 1 (Prm 1) are under translational regulation. Following their transcription in round spermatids, the mRNAs for TP 1 and Prm 1 are stored...