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Keywords: Proline-rich
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Journal Articles

Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration

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Catherine Qiurong Pan, Yih-cherng Liou, Boon Chuan Low
Journal: Journal of Cell Science
J Cell Sci (2010) 123 (6): 903–916.
https://doi.org/10.1242/jcs.064162
Published: 15 March 2010
... to bridge Pin1 and BPGAP1 in a manner that involves the release of an autoinhibited proline-rich motif, 186-PPLP-189, proximal to the RhoGAP domain. This allows the non-canonical 186-PPLP-189 and 256-DDYGD-260 motifs of the proline-rich region and RhoGAP domain of BPGAP1 to become accessible to concerted...
View articletitled, Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration
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Includes: Supplementary data