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Keywords: Proliferation
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Journal Articles
In collection:
Mechanobiology
J Cell Sci (2021) 134 (12): jcs257709.
Published: 21 June 2021
... of the underlying extracellular matrix (ECM), is critically important in regulating cell cycle progression and proliferation. Indeed, increased ECM stiffness causes aberrant cell cycle progression and proliferation. However, the molecular mechanisms that control these stiffness-mediated cellular responses remain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (20): jcs254094.
Published: 30 October 2020
... in nuclear morphology, chromatin organization, and cell proliferation. Human tumor keratinocyte cell lines lacking K17 exhibit flatter nuclei relative to normal. Re-expression of wild-type K17, but not a mutant form lacking an intact nuclear localization signal (NLS), rescues nuclear morphology in KRT17...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (9): jcs237776.
Published: 14 May 2020
...Shanshan Qin; Dan N. Predescu; Monal Patel; Patrick Drazkowski; Balaji Ganesh; Sanda A. Predescu ABSTRACT The sex-biased disease pulmonary arterial hypertension (PAH) is characterized by the proliferation and overgrowth of dysfunctional pulmonary artery endothelial cells (PAECs). During...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (6): jcs222059.
Published: 18 March 2019
... , in cultured Schwann cells and find that tau is present in these cells. Gene silencing of Mapt promoted Schwann cell proliferation and inhibited Schwann cell migration and differentiation. In vivo application of Mapt siRNA suppressed the migration of Schwann cells after sciatic nerve injury. Consistent...
Journal Articles
J Cell Sci (2019) 132 (1): jcs222380.
Published: 02 January 2019
...Jiaoyue Long; Guoning Liao; Yinna Wang; Dale D. Tang ABSTRACT The tyrosine kinase c-Abl participates in the regulation of various cellular functions including cell proliferation, adhesion, migration, smooth muscle contraction and cancer progression. However, knowledge regarding transcriptional...
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2018) 131 (10): jcs215780.
Published: 16 May 2018
... examined the role of extracellular matrix stiffness on human keratinocyte behavior using elastomeric substrates with defined mechanical properties. Increased matrix stiffness beyond normal physiologic levels promoted keratinocyte proliferation but did not alter the ability to self-renew or terminally...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (4): 663–669.
Published: 15 February 2017
... dysregulated pH dynamics influences cancer cell behaviors, including proliferation, metastasis, metabolic adaptation and tumorigenesis. Emerging data suggest that the dysregulated pH of cancers enables these specific cell behaviors by altering the structure and function of selective pH-sensitive proteins...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2016) 129 (18): 3437–3448.
Published: 15 September 2016
...Micheli M. Pillat; Claudiana Lameu; Cleber A. Trujillo; Talita Glaser; Angélica R. Cappellari; Priscilla D. Negraes; Ana M. O. Battastini; Telma T. Schwindt; Alysson R. Muotri; Henning Ulrich ABSTRACT During brain development, cells proliferate, migrate and differentiate in highly accurate patterns...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
J Cell Sci (2016) 129 (12): 2307–2315.
Published: 15 June 2016
... early stages of mouse mammary gland development, its function in the adult gland is not known. Using an inducible RNA interference (RNAi) mouse model for downregulating SCRIB expression, we report an unexpected role for SCRIB as a positive regulator of cell proliferation during pregnancy-associated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (19): 3556–3568.
Published: 01 October 2015
... are well defined, whereas the purpose of RhoC remains poorly understood. Here, we describe how RhoC promotes vascular homeostasis by modulating endothelial cell migration, proliferation and permeability. RhoC stimulates proliferation of human umbilical vein endothelial cells (HUVECs) by stabilizing nuclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (8): 1528–1541.
Published: 15 April 2015
... endothelial cell survival and phenotypic alteration towards proliferation through activation of Erk1 and Erk2 (also known as MAPK3 and MAPK1, respectively). We also show that non‐productive assembly of the Alk5–Smad–SARA (Smad anchor for receptor activation, also known as ZFYVE9) signaling complex...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (24): 5261–5272.
Published: 15 December 2014
...Takashi Nakamura; Yasuo Yoshitomi; Kiyoshi Sakai; Vyomesh Patel; Satoshi Fukumoto; Yoshihiko Yamada ABSTRACT The basal layer of the epidermis contains stem cells and transit amplifying cells that rapidly proliferate and differentiate further into the upper layers of the epidermis. A number...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (21): 4561–4566.
Published: 01 November 2014
...Tom Schilling; Francesc Miralles; Claudia Eder ABSTRACT Ion channels play pivotal roles in regulating important functions of macrophages, such as cytokine and chemokine production, migration, proliferation, phagocytosis and others. In this study, we have identified the transient receptor potential...
Journal Articles
J Cell Sci (2014) 127 (21): 4667–4678.
Published: 01 November 2014
... with that of Notch is that even though, like Notch, integrin mutant PFCs fail to enter endocycle and to differentiate, in contrast to Notch mutants, they do not continue proliferating. The Notch pathway has been shown to regulate the mitotic-to-endocycle transition by independently regulating three mitotic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (20): 4396–4408.
Published: 15 October 2014
... © 2014. Published by The Company of Biologists Ltd 2014 CFTR ZO-1 ZONAB Embryonic development Epithelial remodeling Male fertility Morphogenesis Proliferation Mutations of the cystic fibrosis transmembrane conductance regulator ( CFTR ) gene lead to cystic fibrosis (CF...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (8): 1699–1711.
Published: 15 April 2014
...Francesca Riuzzi; Guglielmo Sorci; Roberta Sagheddu; Angelo Sidoni; Rita Alaggio; Vito Ninfo; Rosario Donato ABSTRACT Embryonal rhabdomyosarcomas (ERMSs) show elevated levels of PAX7, a transcription factor that marks quiescent adult muscle stem (satellite) cells and is important for proliferation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5598–5609.
Published: 15 December 2013
...Valerie S. Salazar; Nicholas Zarkadis; Lisa Huang; Marcus Watkins; Jacqueline Kading; Sheri Bonar; Jin Norris; Gabriel Mbalaviele; Roberto Civitelli Summary Canonical Wnt (cWnt) signaling through β-catenin regulates osteoblast proliferation and differentiation to enhance bone formation. We...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5645–5656.
Published: 15 December 2013
... that there is differential expression of IR-A or IR-B in stem and tumor cells versus differentiated intestinal epithelial cells (IECs) and that IR-B impacts cell proliferation. Our findings provide evidence that IR-B expression is significantly lower in highly proliferative IESCs and progenitor cells versus post-mitotic...
Journal Articles
J Cell Sci (2013) 126 (13): 2867–2876.
Published: 01 July 2013
...Lihi Ninio-Many; Hadas Grossman; Noam Shomron; Dana Chuderland; Ruth Shalgi Summary Fyn, a member of the Src family kinases (SFKs), has a pivotal role in cell adhesion, proliferation, migration and survival, and its overexpression is associated with several types of cancer. MicroRNAs (miRNAs) play...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (13): 2890–2902.
Published: 01 July 2013
... marker osteocalcin in undifferentiated adult bone-marrow-derived rat MSC. Introducing a stable Sox9 knockdown into undifferentiated rat MSC resulted in a marked decrease in proliferation rate and an increase in apoptotic activity. This was linked to a profound upregulation of p21 and cyclin D1 gene...