... ‡ Authors for correspondence ( [email protected] ; [email protected] ) 6 6 2011 © 2011. 2011 Prolactin Transcription Pituitary Development Microscopy Gene expression and the process of transcription is an intensively studied area of cell biology...

... prolactin or growth hormone. We found that DG regulates signaling by both hormones in a manner that is dependent on laminin-111 binding, but independent of the DG cytoplasmic domain, suggesting that it acts via a co-receptor mechanism reliant on DG-mediated laminin assembly. These results demonstrate...

... lactotrophic cells or intact pituitary tissue from bacterial artificial chromosome (BAC) transgenic rats in which a large prolactin genomic fragment directed expression of luciferase or destabilised enhanced green fluorescent protein (d2EGFP). Prolactin promoter activity in transgenic pituitaries varied...

.... Designed after the prolactin promoter-enhancer, it allows for the direct visualization of estrogen receptor α (ERα) and/or Pit-1 interactions at a physiologically regulated transcription locus. ERα- and ligand-dependent cofactor recruitment, large-scale chromatin modifications and transcriptional activity...

... inhibited Pit-1-dependent gene expression. Transcriptional regulation Prolactin Nuclear co-repressor SMRT Nuclear structure Green fluorescent protein Fluorescence microscopy Pit-1 Coactivator and co-repressor protein complexes control gene expression by modifying the acetylation states...

... rat pituitary lactotrophs. Secretory stimulation with high external [K + ] resulted in 100 exocytic sites per cell that were labeled by extracellular antibodies against the peptide hormone prolactin. Morphological analysis demonstrated that the prolactin was retained and internalized in intact dense...

... laminin co-operates with soluble factors such as prolactin to regulate tissue-specific gene expression. The mechanism of matrix and prolactin crosstalk and the activation of downstream signals are not fully understood. Because integrins organize the cytoskeleton, we analysed the contribution...

...Mustapha Lkhider; Barbara Pétridou; Alain Aubourg; Michèle Ollivier-Bousquet ABSTRACT Prolactin added to the incubation medium of lactating mammary epithelial cells is transported from the basal to the apical region of cells through the Golgi region and concomitantly stimulates arachidonic acid...

...Martine Perrot-Applanat; Oreste Gualillo; Helene Buteau; Marc Edery; Paul A. Kelly ABSTRACT Prolactin (PRL) interacts with a specific, well characterized plasma membrane receptor (PRLR) that is coupled to signal transduction pathways involving Jak2, Fyn, and MAP kinases, and signal transducers...

... for correspondence 30 10 1990 19 02 1991 © 1991 by Company of Biologists 1991 microtubules cytokeratin actin pituitary cells secretion prolactin The hypothalamic tripeptide, thyroliberin (TRH), exerts a well-known stimulatory effect on prolactin (PRL) secretion. This effect has...