... lamins in wild-type cells increases cell proliferation, but in cells expressing progerin (a mutant lamin A that causes Hutchinson–Gilford progeria syndrome), low LAP2α levels result in proliferation defects. Here, the aim was to understand the molecular mechanism governing how relative levels of LAP2α...

... of Hutchinson-Gilford progeria syndrome . Proc. Natl. Acad. Sci. USA   102 , 12879 - 12884 . 10.1073/pnas.0506001102 Capell , B. C. , Olive , M. , Erdos , M. R. , Cao , K. , Faddah , D. A. , Tavarez , U. L. , Conneely , K. N. , Qu , X. , San , H. , Ganesh , S. K...

...Zi-Jie Chen; Wan-Ping Wang; Yu-Ching Chen; Jing-Ya Wang; Wen-Hsin Lin; Lin-Ai Tai; Gan-Guang Liou; Chung-Shi Yang; Ya-Hui Chi ABSTRACT Hutchinson-Gilford progeria syndrome (HGPS) is a human progeroid disease caused by a point mutation on the LMNA gene. We reported previously that the accumulation...

...Yiyong Liu; Antonio Rusinol; Michael Sinensky; Youjie Wang; Yue Zou The genetic diseases Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) arise from accumulation of farnesylated prelamin A because of defects in the lamin A maturation pathway. Both of these diseases...

... no effect. The combined results suggest that prelamin A is a poison in cells subjected to FACE 1 knockdown. Finally, we draw attention to similarities in phenotype between FACE1-silenced HeLa cells and fibroblasts from patients with Hutchinson-Gilford progeria syndrome containing prelamin A mutations...