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Keywords: Progeria
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Journal Articles
J Cell Sci (2018) 131 (3): jcs208462.
Published: 8 February 2018
... lamins in wild-type cells increases cell proliferation, but in cells expressing progerin (a mutant lamin A that causes Hutchinson–Gilford progeria syndrome), low LAP2α levels result in proliferation defects. Here, the aim was to understand the molecular mechanism governing how relative levels of LAP2α...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (10): 1975–1980.
Published: 15 May 2016
... of Hutchinson-Gilford progeria syndrome . Proc. Natl. Acad. Sci. USA   102 , 12879 - 12884 . 10.1073/pnas.0506001102 Capell , B. C. , Olive , M. , Erdos , M. R. , Cao , K. , Faddah , D. A. , Tavarez , U. L. , Conneely , K. N. , Qu , X. , San , H. , Ganesh , S. K...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (8): 1792–1804.
Published: 15 April 2014
...Zi-Jie Chen; Wan-Ping Wang; Yu-Ching Chen; Jing-Ya Wang; Wen-Hsin Lin; Lin-Ai Tai; Gan-Guang Liou; Chung-Shi Yang; Ya-Hui Chi ABSTRACT Hutchinson-Gilford progeria syndrome (HGPS) is a human progeroid disease caused by a point mutation on the LMNA gene. We reported previously that the accumulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (22): 4644–4649.
Published: 15 November 2006
...Yiyong Liu; Antonio Rusinol; Michael Sinensky; Youjie Wang; Yue Zou The genetic diseases Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) arise from accumulation of farnesylated prelamin A because of defects in the lamin A maturation pathway. Both of these diseases...
Journal Articles
J Cell Sci (2005) 118 (4): 689–696.
Published: 15 February 2005
... no effect. The combined results suggest that prelamin A is a poison in cells subjected to FACE 1 knockdown. Finally, we draw attention to similarities in phenotype between FACE1-silenced HeLa cells and fibroblasts from patients with Hutchinson-Gilford progeria syndrome containing prelamin A mutations...