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Keywords: Processing
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Journal Articles
J Cell Sci (2008) 121 (17): 2814–2823.
Published: 01 September 2008
... fibrosis, ΔF508, is misfolded and retained by ER quality control. As oligosaccharide moieties of glycoproteins are known to mediate interactions with ER lectin chaperones, we investigated the role of N-linked glycosylation in the processing of wild-type and ΔF508 CFTR. We found that N-glycosylation and ER...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (11): 2249–2258.
Published: 01 May 2004
... is synthesized as a 65 kDa non-active precursor that subsequently undergoes proteolytic cleavage, yielding 8 kDa and 50 kDa protein subunits that heterodimerize to form an active enzyme. The protease responsible for heparanase processing is currently unknown, as is the sub-cellular processing site. In this study...
Journal Articles
J Cell Sci (2002) 115 (21): 4025–4036.
Published: 01 November 2002
.... Correctly processed PrP traffics to the cell surface where it is anchored to the plasma membrane by its GPI moiety( Rogers et al., 1991 ). We investigated the subcellular location of recombinant wild-type and disease-associated mutant PrP by IF microscopy. Very recently, it has been observed that mutant PrP...
Journal Articles
J Cell Sci (2002) 115 (10): 2179–2187.
Published: 15 May 2002
...Liat Nadav; Amiram Eldor; Oron Yacoby-Zeevi; Eli Zamir; Iris Pecker; Neta Ilan; Benjamin Geiger; Israel Vlodavsky; Ben-Zion Katz Heparanase is a heparan-sulfate-degrading endoglycosidase that has important roles in various biological processes, including angiogenesis, wound healing and metastatsis...
Journal Articles
J Cell Sci (2002) 115 (3): 563–574.
Published: 01 February 2002
... and during storage in the micronemes. TgMIC6 is processed at the N-terminus, probably in the trans-Golgi network, and the cleavage site has been precisely mapped. Additionally, like other members of the thrombospondin-related anonymous protein family, TgMIC2, TgMIC6 and TgMIC8 are proteolytically cleaved...
Journal Articles
J Cell Sci (1993) 1993 (Supplement_17): 235–239.
Published: 01 December 1993
..., the apical membrane of CF airway epithelia is Cl − -impermeable, a defect that probably contributes to the pathogenesis of the disease. © The Company of Biologists Limited 1993 1993 cystic fibrosis chloride channel processing trafficking apical membrane Journal of Cell Science, Supplement 17...