...Jovana Deretic; Ezgi Odabasi; Elif Nur Firat-Karalar ABSTRACT The primary cilium is a conserved microtubule-based organelle that is critical for transducing developmental, sensory and homeostatic signaling pathways. It comprises an axoneme with nine parallel doublet microtubules extending from...

... – the primary cilium – as a sensory antenna, have since been extensively studied, but the role of the cilium–centrosome axis in cell fate is still emerging. In this Opinion piece, we view cellular quiescence and tissue homeostasis from the vantage point of the cilium–centrosome axis. We focus on a less explored...

.... and Schneider , L. ( 2008 ). Chapter 10 The primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair . Curr. Top. Dev. Biol. 85 , 261 - 301 . 10.1016/S0070-2153(08)00810-7 Curto , M. , Cole , B. K. , Lallemand , D...

...Ezgi Odabasi; Deniz Conkar; Jovana Deretic; Umut Batman; Kari-Anne M. Frikstad; Sebastian Patzke; Elif Nur Firat-Karalar ABSTRACT The primary cilium is a microtubule-based organelle that serves as a hub for many signaling pathways. It functions as part of the centrosome or cilium complex, which...

....200205102 Kim , S. and Dynlacht , B. D. ( 2013 ). Assembling a primary cilium . Curr. Opin. Cell Biol. 25 , 506 - 511 . 10.1016/j.ceb.2013.04.011 Kim , J. , Krishnaswami , S. R. and Gleeson , J. G. ( 2008a ). CEP290 interacts with the centriolar satellite...

...Chiara Cassioli; Anna Onnis; Francesca Finetti; Nagaja Capitani; Jlenia Brunetti; Ewoud B. Compeer; Veronika Niederlova; Ondrej Stepanek; Michael L. Dustin; Cosima T. Baldari ABSTRACT Components of the intraflagellar transport (IFT) system that regulates the assembly of the primary cilium are co...

... centrin 2 reveals a separation of functions whereby centrin 2 that is defective in calcium binding can support nucleotide excision repair but not primary ciliogenesis. Primary cilium Centrosome Centriole Centrin 2 CETN2 Nucleotide excision repair Science Foundation Ireland 10.13039...

...Peter Satir; Birgit H. Satir ABSTRACT Many signaling molecules are localized to both the primary cilium and nucleus. Localization of specific transmembrane receptors and their signaling scaffold molecules in the cilium is necessary for correct physiological function. After a specific signaling...

...Ching-Ju Hsiao; Chia-Hsiang Chang; Ridwan Babatunde Ibrahim; I-Hsuan Lin; Chun-Hung Wang; Won-Jing Wang; Jin-Wu Tsai ABSTRACT The primary cilium is a tiny cell protrusion known to transduce key extracellular signals, including those of the sonic hedgehog pathway, which activates Gli transcription...

... is required for centrosomal and nuclear attachment, and photoreceptor outer segment formation. Pericentrin Syne-2 Nuclear migration Primary cilium Ciliogenesis Retina CRISPR/Cas9 Deutsche Forschungsgemeinschaft 10.13039/501100001659 GI 770 1-1/1-2 Charlotte & Tistou...

... carried by the mother centriole that is required for primary cilium formation. Recent data have implicated CEP164 as a ciliopathy gene and suggest that CEP164 plays some roles in the DNA damage response (DDR). We used reverse genetics to test the role of CEP164 in the DDR. We found that conditional...

...Yi Shan Lim; Bor Luen Tang ABSTRACT The small GTPase Rab23 is an antagonist of sonic hedgehog (Shh) signaling during mouse development. Given that modulation of Shh signaling depends on the normal functioning of the primary cilium, and overexpression of Evi5L, a putative Rab23 GTPase-activating...

... of AC5 and AC6 represses, whereas their knockdown activates, the Hh pathway in CGNPs and in the embryonic neural tube. Indeed, AC5 and AC6 concentrate in the primary cilium, and mutation of a previously undescribed cilium-targeting motif in AC5 suppresses its ciliary location, as well as its capacity...

... PtdIns(3,4) P 2 and phosphatidylinositol 4-phosphate [PtdIns(4) P ], respectively, creating second messengers that mediate cell responses to various stimuli ( Conduit et al., 2012 ). INPP5E localizes to the primary cilium, and Inpp5e −/− mice develop ciliopathic phenotypes including polycystic...

...Hongzhong Wang; Xinle Zou; Zhuang Wei; Yuan Wu; Rongxia Li; Rong Zeng; Zhengjun Chen; Kan Liao ABSTRACT The primary cilium is composed of an axoneme that protrudes from the cell surface, a basal body beneath the membrane and a transition neck in between. It is a sensory organelle on the plasma...

... and CCDC116 as centrosome-associated proteins. We examined the highly conserved protein CCDC113 further and found that it is a component of centriolar satellites, is in a complex with the satellite proteins HAP1 and PCM1, and functions in primary cilium formation. References Avidor-Reiss   T...

... with the actin-based cytoskeleton and microtubules. They are involved in scaffolding functions, and form diffusion barriers in budding yeast, the sperm flagellum and the base of primary cilia of kidney epithelial cells. We investigated the role of septins in the primary cilium of retinal pigmented epithelial...

.... , Haycraft   C. J. , Yoder   B. K. ( 2009 ). The primary cilium as a complex signaling center.   Curr. Biol.   19 , R526 – R535 . 10.1016/j.cub.2009.05.025 Bornens   M. ( 2002 ). Centrosome composition and microtubule anchoring mechanisms.   Curr. Opin. Cell Biol.   14 , 25 – 34...

...), a previously uncharacterized and highly conserved protein that is required for normal formation of a primary cilium. FOR20 is found in PCM1-enriched pericentriolar satellites and centrosomes. FOR20 contains a Lis1-homology domain that promotes self-interaction and is required for its satellite localization...

... in multiple cellular functions. The primary cilium is generally non motile and found in numerous vertebrate cell types where it controls key signalling pathways. Despite a common architecture, ultrastructural data suggest some differences in their organisation. Here, we report the first detailed...