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Keywords: Primary cilia
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Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2022) 135 (18): jcs260021.
Published: 15 September 2022
...Tetsuo Kobayashi; Tatsuya Ikeda; Reo Ota; Takafumi Yasukawa; Hiroshi Itoh ABSTRACT Primary cilia are near-ubiquitously assembled on cells in the human body, and are broadly associated with genetic diseases and cancers. In the early stage of ciliogenesis, the ciliary vesicle (CV) is formed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (12): jcs259471.
Published: 24 June 2022
... to the base of the primary cilium, but is not a cargo of KIF13B itself. Consistent with a ciliary function for Ap80, its depletion led to elongated primary cilia and reduced agonist-induced ciliary accumulation of SMO, a key component of the Hedgehog signaling pathway, whereas Ap80 overexpression caused...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (11): jeb258608.
Published: 8 June 2022
.../journal.pone.0081769 Bangs , F. K. , Schrode , N. , Hadjantonakis , A. K. and Anderson , K. V. ( 2015 ). Lineage specificity of primary cilia in the mouse embryo . Nat. Cell Biol. 17 , 113 - 122 . 10.1038/ncb3091 Blaess , S. ( 2006 ). Sonic hedgehog regulates Gli...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs255562.
Published: 24 December 2020
..., which forms an ion channel in primary cilia and endoplasmic reticulum (ER) membranes of renal collecting duct cells. Elevated internal Ca 2+ modulates polycystin-2 voltage-dependent gating and subsequent desensitization – two biophysical regulatory mechanisms that control its function at physiological...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (21): jcs249789.
Published: 9 November 2020
...://jcs.biologists.org/lookup/doi/10.1242/jcs.249789.reviewer-comments.pdf References Anvarian , Z. , Mykytyn , K. , Mukhopadhyay , S. , Pedersen , L. B. and Christensen , S. T. ( 2019 ). Cellular signalling by primary cilia in development, organ function and disease . Nat. Rev. Nephrol...
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Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2020) 133 (13): jcs239871.
Published: 8 July 2020
... and homeostasis, limiting the potential for these pathways to be targeted therapeutically. Primary cilia are subcellular regulators of cellular signalling, controlling how signalling is organized, encoded and, in some instances, driving or influencing pathogenesis. Our previous research revealed that disruption...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2020) 133 (11): jcs243113.
Published: 8 June 2020
.... , Canter , B. and Dynlacht , B. D. ( 2014 ). Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma . Proc. Natl. Acad. Sci. USA   111 , 9151 - 9156 . 10.1073/pnas.1323265111 Fu , J. , Hagan , I. M. and Glover , D. M...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (2): jcs224428.
Published: 16 January 2019
... in the organelle. Certain G-protein-coupled receptors (GPCRs) specifically localize to the membrane compartment of primary cilia. To gain insight into the mechanisms that regulate ciliary GPCR sorting, we investigated the atypical small GTPase RAB-like 2 (RABL2; herein referring to the near-identical human...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2018) 131 (24): jcs219923.
Published: 14 December 2018
...Pratim Chowdhury; Reid T. Powell; Clifford Stephan; Ivan P. Uray; Tia Talley; Menuka Karki; Durga Nand Tripathi; Yong Sung Park; Michael A. Mancini; Peter Davies; Ruhee Dere ABSTRACT Loss of the gene von Hippel–Lindau ( VHL ) is associated with loss of primary cilia and is causally linked...
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Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2018) 131 (24): jcs219527.
Published: 12 December 2018
...Tomoaki Nagai; Sachiho Mukoyama; Harumi Kagiwada; Naoki Goshima; Kensaku Mizuno ABSTRACT Primary cilia are antenna-like sensory organelles that transmit various extracellular signals. Ciliogenesis requires the removal of CP110 and its interactor CEP97 from the mother centriole for initiating...
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Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2018) 131 (16): jcs217828.
Published: 20 August 2018
...Emily R. Moore; Yuchen Yang; Christopher R. Jacobs ABSTRACT Although Prx1 (also known as PRRX1)-expressing cells and their primary cilia are critical for embryonic development, they have yet to be studied in the context of postnatal skeletogenesis owing to the lethality of mouse models. A tamoxifen...
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Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2018) 131 (9): jcs212324.
Published: 4 May 2018
... binds tubulin to maintain uniform distribution of proteins along the ciliary membrane. Primary cilia Arl13b Ciliopathies Joubert syndrome Ciliary membrane Small GTPase Tubulin Axoneme Primary cilia are elongated protrusions of the cellular membrane where components of multiple...
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Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2017) 130 (20): 3447–3454.
Published: 15 October 2017
... ) Competing interests The authors declare no competing or financial interests. 20 12 2016 29 8 2017 © 2017. Published by The Company of Biologists Ltd 2017 http://www.biologists.com/user-licence-1-1/ Summary: Lack of OCRL elevates PI(4,5)P 2 levels in primary cilia of human...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (19): 3543–3549.
Published: 1 October 2015
...Brian S. Nielsen; Raj R. Malinda; Fabian M. Schmid; Stine F. Pedersen; Søren T. Christensen; Lotte B. Pedersen ABSTRACT Primary cilia are microtubule-based sensory organelles projecting from most quiescent mammalian cells, which disassemble in cells cultured in serum-deprived conditions upon re...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (24): 5317–5330.
Published: 15 December 2014
... Compartmentalization Primary cilia Sensory neuron Thermotaxis Transition zone It is also unclear how different modules of ciliary proteins affect cGMP signaling. Many proteins disrupted in BBS patients assemble into a complex called the ‘BBSome’ ( Nachury et al., 2007 ). This multimeric assembly functions...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (7): 1500–1510.
Published: 1 April 2014
... ). We observed that Gli2 and other Hh signal transduction components, including Sufu and Smo, also localize to primary cilia in mouse ESCs ( supplementary material Fig. S2A ). Similarly, the majority of Gli2 Gli2−GFP/+ ESCs exhibited GFP at the ciliary tip, as defined by co-staining with the basal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (4): 953–965.
Published: 15 February 2013
... Christensen   S. T. , Clement   C. A. , Satir   P. , Pedersen   L. B. ( 2012 ). Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling.   J. Pathol.   226 , 172 – 184 . 10.1002/path.3004 Denker   S. P. , Barber   D. L. ( 2002 ). Cell migration requires both...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (18): 4297–4305.
Published: 15 September 2012
...Natalia V. Prodromou; Clare L. Thompson; Daniel P. S. Osborn; Kathryn F. Cogger; Rachel Ashworth; Martin M. Knight; Philip L. Beales; J. Paul Chapple Summary Primary cilia are involved in important developmental and disease pathways, such as the regulation of neurogenesis and tumorigenesis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (8): 1945–1957.
Published: 15 April 2012
... )–Cre with Kif3a flox/null mice. Conditional Kif3a -null mice ( Kif3a Oc-cKO ) had a 75% reduction in Kif3a transcripts in bone and osteoblasts. Conditional deletion of Kif3a resulted in the reduction of primary cilia number by 51% and length by 27% in osteoblasts. Kif3a Oc-cKO mice developed osteopenia...
Journal Articles
J Cell Sci (2012) 125 (5): 1353–1362.
Published: 1 March 2012
...Julia Vulprecht; Ahuvit David; Alexandra Tibelius; Asher Castiel; Gleb Konotop; Fengying Liu; Felix Bestvater; Marc S. Raab; Hanswalter Zentgraf; Shai Izraeli; Alwin Krämer Centrioles are key structural elements of centrosomes and primary cilia. In mammals, only a few proteins including PLK4, CPAP...
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