... synaptic N-methyl-D-aspartate (NMDA) receptors. We show that tPA treatment increases the abundance of p35 and its binding to Cdk5 in the postsynaptic density (PSD). Furthermore, our data indicate that tPA-induced p35-mediated Cdk5 activation does not induce cell death, but instead prevents NMDA-induced...

.... (2005). Internalized GABA A -receptor subunits are transferred to an intracellular pool associated with the postsynaptic density. Eur. J. Neurosci. 21 , 327 -338. Varoqueaux, F., Aramuni, G., Rawson, R. L., Mohrmann, R., Missler, M., Gottmann, K., Zhang, W., Suedhof, T. C. and Brose, N. (2006...

.... and Kim, E. (2003). The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the βPix guanine nucleotide exchange factor for Rac1 and Cdc42. J. Biol. Chem. 278 , 19220 -19229. Penzes, P., Johnson, R. C., Sattler, R., Zhang, X., Huganir, R. L...

...Daijiro Konno; Ji-Ae Ko; Shinichi Usui; Kei Hori; Hisato Maruoka; Makoto Inui; Takashi Fujikado; Yasuo Tano; Tatsuo Suzuki; Koujiro Tohyama; Kenji Sobue The postsynaptic site of the excitatory synapse, which is composed of the postsynaptic density (PSD) attached to the postsynaptic membrane...

... domain, a PDZ domain, a long proline-rich region, and a SAM domain. Binding partners for most of these domains have been identified: for instance, the PDZ domain of Shank proteins interacts with GKAP (a postsynaptic-density protein) as well as several G-protein-coupled receptors. The specific...