... of autophagy in mammalian cells with a focus on cancer. Post-translational modification Transcription Translation National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 GM131919 Macroautophagy (hereafter, autophagy) is an evolutionarily conserved...

...Danya Abazari; Angela R. Wild; Tian Qiu; Bryan C. Dickinson; Shernaz X. Bamji ABSTRACT Activity-induced changes in protein palmitoylation can regulate the plasticity of synaptic connections, critically impacting learning and memory. Palmitoylation is a reversible post-translational modification...

... be the target of post-translational modifications other than SUMOylation, the ability of K393 to undergo ubiquitylation was assessed using an ubiquitin-based BiFC assay. Although ZIC5 was found to be ubiquitylated, K393 was not a target lysine ( Fig. S4D ). If, as indicated by the TOPflash and BiFC...

... domain, and regulates plasma membrane targeting. Sprouty-2 Post-translational modification PTM S-acylation ZDHHC enzymes Palmitoylation Biotechnology and Biological Sciences Research Council 10.13039/501100000268 BB/L022087/1 Medical Research Council 10.13039...

... of Biologists Ltd 2020 Summary: In this Review, we highlight recent work identifying non-transcriptional mechanisms crucial to regulating the core mammalian clock proteins and their role in circadian rhythmicity. Circadian rhythm Post-transcriptional modification Post-translational modification...

... microtubule bundles bridging daughter cells are severed. Here, we present a novel abscission mechanism. We identified chromokinesin KIF4A, which is adjacent to the midbody during cytokinesis, as being required for efficient abscission. KIF4A is regulated by post-translational modifications. We evaluated...

... changes in the composition of, or post-translational modifications to ribosomal subunit proteins (RPs). We recently found that poxviruses phosphorylate unique sites in the RP, receptor for activated C kinase 1 (RACK1) to enhance viral protein synthesis. Here, we developed approaches for large-scale...

... and migration to development and tissue function. Actins have different post-translational modifications (PTMs) in different organisms, including methionine, alanine, aspartate and glutamate N-acetylation, N-arginylation and the methylation of the histidine at residue 73 (His-73), with different organisms...

... in chromatin organization. Chromatin Enhancer Post-translational modification Stress response Transcription Academy of Finland 10.13039/501100002341 Stiftelsen för Åbo Akademi 10.13039/501100007360 Sigrid Juséliuksen Säätiö 10.13039/501100006306 Magnus...

... and, hence, many cellular key functions. Here, we review the current knowledge on function and regulation of SENP proteins. SENP SUMO Post-translational modification Deutsche Forschungsgemeinschaft 10.13039/501100001659 MU-1764/4 SFB815 SFB1177 Small ubiquitin-related modifier...

...-licence-1-1/ Summary: Different sheddases specifically and dynamically distinguish between multiple substrates expressed on the same cell, in a process regulated by Ca 2+ coordination of the Shh substrate. Morphogenesis Hedgehog signaling Shedding regulation Post-translational...

... as suspicious and inhibits exosome secretion to prevent the spreading of pathogens and protein aggregates. Exosomes ISG15 Pathogen Post-translational modification Ubiquitin-like Ministerio de Economía y Competitividad SAF 2014-55579-R SAF 2014-54623 Instituto de Salud Carlos III...

... of an endoplasmic reticulum (ER)-targeting signal peptide; hence, the mechanism of extracellular secretion is not completely understood, although HMGB1 is secreted after being subjected to post-translational modifications. Here, we identified the role of N-glycosylation of HMGB1 in extracellular secretion. We found...

.... © 2014. Published by The Company of Biologists Ltd 2014 O -GlcNAc O -GlcNAcylation Metabolism Post-translational modification Signaling Lipid droplets Mitochondria Epigenetics Nuclear pores Hundreds of proteins are modified at the hydroxyl group of their serine and threonine...

... ). Distinct cytoskeletal tracks direct individual vesicle populations to the apical membrane of epithelial cells.   Curr. Biol.   13 , 607 – 612 . 10.1016/S0960-9822(03)00188-X Janke   C. , Kneussel   M. ( 2010 ). Tubulin post-translational modifications: encoding functions on the neuronal...

... migration, and examine exciting evidence on the regulation of nestin and lamin A by the notch signalling pathway, which could have repercussions for our understanding of the roles of IF proteins in development and ageing. In addition, we discuss the modulation of the post-translational modifications...

... Crithidia NIMA kinases Polyglutamylation Tubulin Post-translational modification Cell cycle Microtubules are ubiquitous cytoskeletal elements that perform essential functions during cell division, movement, intracellular transport and generation of cell shape. The great diversity of tubulins...

... Post-translational modification Polyglutamylation Trypanosomatid Tubulin Microtubules are necessary for cell division, directed intracellular transport, the beating of cilia and flagella and the dynamic organisation of cell morphology. The structural unit of microtubules is the αβ...

.... H. ( 1997 ). Tubulin post-translational modifications-enzymes and their mechanisms of action . Eur. J. Biochem . 244 , 265 – 278 . Martensen , T. M. ( 1982 ). Preparation of brain tyrosinotubulin carboxypeptidase . Meth. Cell Biol . 24 , 265 – 269 . Maxwell , S...

...Michel Laurent; Anne Fleury ABSTRACT At the epigenetic level, microtubule diversity is generated by several mechanisms of reversible post-translational modifications of tubulin subunits. In most cases, modification enzymes preferentially act on the tubulin subunits of microtubules, whereas...