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Keywords: Polymerized actin
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Journal Articles
Epithelial plasticity in COPD results in cellular unjamming due to an increase in polymerized actin
Open AccessBaishakhi Ghosh, Kristine Nishida, Lakshmana Chandrala, Saborny Mahmud, Shreeti Thapa, Carter Swaby, Si Chen, Atulya Aman Khosla, Joseph Katz, Venkataramana K. Sidhaye
Journal:
Journal of Cell Science
J Cell Sci (2022) 135 (4): jcs258513.
Published: 24 February 2022
... epithelial-to-mesenchymal transition (pEMT), albeit with distinct cell motion indicative of cellular unjamming. These injured/diseased cells have an increased fraction of polymerized actin, due to loss of the actin-severing protein cofilin-1. We observed that decreasing polymerized actin restores the jammed...
Includes: Supplementary data
