...Mamata Malla; Debatrayee Sinha; Pritha Chowdhury; Benjamin Thomas Bisesi; Qian Chen ABSTRACT Polycystins are a family of conserved ion channels, mutations of which lead to one of the most common human genetic disorders, namely, autosomal dominant polycystic kidney disease. Schizosacchromyces pombe...

...Peiwei Liu; Ying Liu; Jun Zhou ABSTRACT Cilia are surface-exposed organelles that provide motility and sensory functions for cells, and it is widely believed that mechanosensation can be mediated through cilia. Polycystin-1 and -2 (PC-1 and PC-2, respectively) are transmembrane proteins that can...

...Debatrayee Sinha; Denisa Ivan; Ellie Gibbs; Madhurya Chetluru; John Goss; Qian Chen ABSTRACT Polycystins are conserved mechanosensitive channels whose mutations lead to the common human renal disorder autosomal dominant polycystic kidney disease (ADPKD). Previously, we discovered that the plasma...

...Thuy N. Vien; Leo C. T. Ng; Jessica M. Smith; Ke Dong; Matteus Krappitz; Vladimir G. Gainullin; Sorin Fedeles; Peter C. Harris; Stefan Somlo; Paul G. DeCaen ABSTRACT Approximately 15% of autosomal dominant polycystic kidney disease (ADPKD) is caused by variants in PKD2 . PKD2 encodes polycystin-2...

... in certain epithelial and endothelial cells, however, it is reasonable to speculate that at least three of these players, monocilia, gap junction communication and the Ca 2+ channel polycystin-2, participate in a signalling pathway that propagates left-right cues through multicellular fields. (e...