... to stabilize centromere protein levels and accurate mitotic segregation. Pericentric heterochromatin levels can also recover after severe depletion. Centromere Heterochromatin Polycomb Mitosis Kinetochore CENP-A Human artificial chromosome Epigenetic engineering Wellcome Trust 10.13039...

... , 185 - 193 . 10.1093/bioinformatics/19.2.185 Boyer , L. A. , Plath , K. , Zeitlinger , J. , Brambrink , T. , Medeiros , L. A. , Lee , T. I. , Levine , S. S. , Wernig , M. , Tajonar , A. , Ray , M. K. , et al. ( 2006 ). Polycomb complexes repress...

...Mónica Bravo; Fabio Nicolini; Katarzyna Starowicz; Sonia Barroso; Carmela Calés; Andrés Aguilera; Miguel Vidal ABSTRACT The functions of polycomb products extend beyond their well-known activity as transcriptional regulators to include genome duplication processes. Polycomb activities during DNA...

...Joseph H. A. Vissers; Maarten van Lohuizen; Elisabetta Citterio Summary Polycomb group (PcG) genes encode chromatin modifiers that are involved in the maintenance of cell identity and in proliferation, processes that are often deregulated in cancer. Interestingly, besides a role in epigenetic gene...

... is quantitative and increases with the duration of exposure to cold. Vernalization involves a Polycomb-based switching mechanism, with localized nucleation of silencing during periods of cold, and spreading of the silencing complex over the whole gene after the exposure to cold. A number of characteristics...

... cells and transit amplifying and differentiating cells are restricted to the crypts. The polycomb group (PcG) proteins repress differentiation and promote self-renewal in embryonic stem cells. PcGs prevent transcriptional activity by catalysing epigenetic modifications, such as the covalent addition...

... Neurogenesis Neural stem cells HAT Histone acetyltransferase Fluorescence-activated cell sorting Polycomb We have previously shown that a lack of the MYST-family histone acetyltransferase, QKF, leads to defects in the establishment and self-renewal of adult NSCs and consequently to a progressive...

...Jan Willem Voncken; Dieter Schweizer; Louise Aagaard; Lydia Sattler; Michael F. Jantsch; Maarten van Lohuizen ABSTRACT The human proto-oncogene Bmi1 is a member of the mammalian Polycomb Group (Pc-G) genes. The subnuclear distribution of the BMI1 protein was studied in several primary human...