...Hendrik Schürmann; Fatemeh Abbasi; Antonella Russo; Arne D. Hofemeier; Matthias Brandt; Johannes Roth; Thomas Vogl; Timo Betz ABSTRACT Podosomes are mechanosensitive protrusive actin structures that are prominent in myeloid cells, and they have been linked to vascular extravasation. Recent studies...

... sealing zones that enable them to adhere to and resorb bone. Sealing zones consist of densely packed podosomes tightly interconnected by actin fibers. Their formation requires the presence of the hematopoietic integrin regulator kindlin-3 (also known as Fermt3). In this study, we investigated osteoclasts...

...Yuhuan Zhou; Zhen Feng; Fakun Cao; Xiaoting Liu; Xiaojie Xia; Cheng-han Yu ABSTRACT Podosomes play crucial roles in macrophage adhesion and migration. Wiskott–Aldrich syndrome protein (WASP; also known as WAS)-mediated actin polymerization is one of the key events initiating podosome formation...

...Koen van den Dries; Stefan Linder; Isabelle Maridonneau-Parini; Renaud Poincloux ABSTRACT Podosomes are dynamic adhesion structures formed constitutively by macrophages, dendritic cells and osteoclasts and transiently in a wide variety of cells, such as endothelial cells and megakaryocytes...

... their participation in adhesion turnover and cellular signalling. In this Review, we focus on the interactions between microtubules and integrin-mediated adhesions, in particular, focal adhesions and podosomes. Starting with the association of microtubules with these adhesive structures, we describe the classical...

... of Biologists Ltd 2019 Summary: Cell–cell fusion is promoted by invasive protrusions and mechanosensory responses at the asymmetric fusogenic synapse. Actin cytoskeleton Cell–cell fusion Fusogenic synapse Invasive protrusion Mechanical force Mechanosensory response Myoblast fusion Podosome...

...Matthew R. Miller; Eric W. Miller; Scott D. Blystone ABSTRACT Having previously located the formin FMNL1 in macrophage podosomes, we developed an in vivo model to assess the role of FMNL1 in the migration activities of primary macrophages. Deletion of FMNL1 in mice was genetically lethal; however...

...Heiani Touaitahuata; Anne Morel; Serge Urbach; Julio Mateos-Langerak; Sylvain de Rossi; Anne Blangy ABSTRACT Bone resorption by osteoclasts is mediated by a typical adhesion structure called the sealing zone or actin ring, whose architecture is based on a belt of podosomes. The molecular mechanisms...

...Julie Di Martino; Elodie Henriet; Zakaria Ezzoukhry; Jacky G. Goetz; Violaine Moreau; Frederic Saltel ABSTRACT Invadosomes are actin-based structures involved in extracellular matrix degradation. Invadosomes is a term that includes podosomes and invadopodia, which decorate normal and tumour cells...

...Vineetha Vijayakumar; James Monypenny; Xing Judy Chen; Laura M. Machesky; Sergio Lilla; Adrian J. Thrasher; Inés M. Antón; Yolanda Calle; Gareth E. Jones ABSTRACT Podosomes are integrin-containing adhesion structures commonly found in migrating leukocytes of the monocytic lineage. The actin...

...Nadia Efimova; Ashley Grimaldi; Alice Bachmann; Keyada Frye; Xiaodong Zhu; Alexander Feoktistov; Anne Straube; Irina Kaverina ABSTRACT The kinesin KIF1C is known to regulate podosomes, actin-rich adhesion structures that remodel the extracellular matrix during physiological processes. Here, we show...

... mechanosensitive adhesive structures called podosomes that consist of an actin-rich core surrounded by integrins, adaptor proteins and actin network filaments. They facilitate cell migration via localized degradation of extracellular matrix. Here, we show that podosomes of human dendritic cells locate to spots...

...Daisuke Hoshino; Kevin M. Branch; Alissa M. Weaver Summary Remodeling of extracellular matrix (ECM) is a fundamental cell property that allows cells to alter their microenvironment and move through tissues. Invadopodia and podosomes are subcellular actin-rich structures that are specialized...

...Tomasz J. Proszynski; Joshua R. Sanes Summary Neuromuscular junctions (NMJs) in mammalian skeletal muscle undergo a postnatal topological transformation from a simple oval plaque to a complex branched structure. We previously showed that podosomes, actin-rich adhesive organelles, promote...

...Yi-Ru Pan; Ke-Huan Cho; Hsiao-Hui Lee; Zee-Fen Chang; Hong-Chen Chen Summary Podosomes are actin-enriched membrane protrusions that play important roles in extracellular matrix degradation and invasive cell motility. Podosomes undergo self-assembly into large rosette-like structures in Src...

...Chen Luxenburg; Sabina Winograd-Katz; Lia Addadi; Benjamin Geiger Podosomes, which are formed by different monocyte derivatives, are small adhesion structures whose coordinated dynamics and cytoskeletal reorganization drive their motile and invasive features. Using live-cell microscopy, we explored...

... of actin assembly, podosome clusters and clusters of zipper-like structures. The zipper-like structures morphologically resembled the adhesion zippers found at the initial stage of cell–cell adhesion in keratinocytes. In the zipper-like structure, Arp3 and cortactin overlapped with the distribution...

...Miho Kuroiwa; Chitose Oneyama; Shigeyuki Nada; Masato Okada Podosomes and invadopodia are actin-rich membrane protrusions that play a crucial role in cell adhesion and migration, and extracellular matrix remodeling in normal and cancer cells. The formation of podosomes and invadopodia is promoted...

...Christian Gawden-Bone; Zhongjun Zhou; Emma King; Alan Prescott; Colin Watts; John Lucocq Podosomes are spot-like actin-rich structures formed at the ventral surface of monocytic and haematopoietic cells. Podosomes degrade extracellular matrix and are proposed to be involved in cell migration. A key...

...' activity might have additional roles in this and other settings. [email protected] © The Company of Biologists Limited 2009 2009 Leukocyte Endothelium Diapedesis Podosome Invadopodia Invadosome Migration Transcellular This article is part of a Minifocus...