.... ( 2013 ). The podocyte slit diaphragm--from a thin grey line to a complex signalling hub . Nat. Rev. Nephrol. 9 , 587 - 598 . 10.1038/nrneph.2013.169 Haruhara , K. , Kanzaki , G. , Sasaki , T. , Hatanaka , S. , Okabayashi , Y. , Puelles , V. G. , Harper , I. S...

... consequences of nephrin clustering are not well understood. Here, we demonstrate that nephrin phosphorylation regulates the formation of membrane clusters in podocytes. We also reveal a connection between clustering and endocytosis, which appears to be driven by threshold levels of nephrin tyrosine...

...Koichiro Ichimura; Soichiro Kakuta; Yuto Kawasaki; Takayuki Miyaki; Takahiro Nonami; Naoyuki Miyazaki; Tomoyo Nakao; Sakiko Enomoto; Shigeo Arai; Masato Koike; Kazuyoshi Murata; Tatsuo Sakai; Andrew Ewald ABSTRACT Podocytes present a unique 3D architecture specialized for glomerular filtration...

...Abass Al-Momany; Laiji Li; R. Todd Alexander; Barbara J. Ballermann ABSTRACT CLIC5A (encoded by CLIC5 ) is a component of the ezrin–NHERF2–podocalyxin complex in renal glomerular podocyte foot processes. We explored the mechanism(s) by which CLIC5A regulates ezrin function. In COS-7 cells, CLIC5A...

... for this process. Using biologically and clinically relevant glomerular podocytes as a model system, we show that integrin activation and dependent processes are tightly regulated by kindlin-2: depletion of kindlin-2 reduced integrin activation, matrix adhesion and fibronectin matrix deposition, whereas...

...Gary Davidson; Rosanna Dono; Rolf Zeller To examine the potential role of fibroblast growth factor (FGF) signalling during cell differentiation, we used conditionally immortalised podocyte cells isolated from kidneys of Fgf2 mutant and wild-type mice. Wild-type mouse podocyte cells upregulate FGF2...