...Federico Pecori; Yoshihiro Akimoto; Hisatoshi Hanamatsu; Jun-ichi Furukawa; Yasuro Shinohara; Yuzuru Ikehara; Shoko Nishihara ABSTRACT Mouse embryonic stem cells (ESCs) can differentiate into a range of cell types during development, and this pluripotency is regulated by various extrinsic...

...Maiko Yamamoto; Yoshiaki Suwa; Kohta Sugiyama; Naoki Okashita; Masanori Kawaguchi; Naoki Tani; Kazumi Matsubara; Akira Nakamura; Yoshiyuki Seki ABSTRACT The pluripotency-associated transcriptional network is regulated by a core circuitry of transcription factors. The PR domain-containing protein...

...Lotte Vanheer; Juan Song; Natalie De Geest; Adrian Janiszewski; Irene Talon; Caterina Provenzano; Taeho Oh; Joel Chappell; Vincent Pasque ABSTRACT Reprogramming to induced pluripotency induces the switch of somatic cell identity to induced pluripotent stem cells (iPSCs). However, the mediators...

... and cancer. Roles of the Smc5/6 structural maintenance of chromosomes complex in pluripotent stem cell genome maintenance have not been investigated, despite its important roles in DNA synthesis, DNA repair and chromosome segregation as evaluated in other model systems. Using mouse embryonic stem cells...

...Bernhard Münst; Marc Christian Thier; Dirk Winnemöller; Martina Helfen; Rajkumar P. Thummer; Frank Edenhofer ABSTRACT A comprehensive analysis of the molecular network of cellular factors establishing and maintaining pluripotency as well as self renewal of pluripotent stem cells is key for further...

...Jong Soo Kim; Hyun Woo Choi; Marcos J. Araúzo-Bravo; Hans R. Schöler; Jeong Tae Do ABSTRACT Direct reprogramming of somatic cells to pluripotent stem cells entails the obliteration of somatic cell memory and the reestablishment of epigenetic events. Induced pluripotent stem cells (iPSCs) have been...

...Tim Pieters; Frans van Roy ABSTRACT Pluripotent embryonic stem cells (ESCs) can self-renew or differentiate into any cell type within an organism. Here, we focus on the roles of cadherins and catenins – their cytoplasmic scaffold proteins – in the fate, maintenance and differentiation of mammalian...

...Chih-I Tai; Qi-Long Ying Summary Activation of signal transducer and activator of transcription 3 (Stat3) by leukemia inhibitory factor (LIF) maintains mouse embryonic stem cell (mESC) self-renewal and also facilitates reprogramming to ground state pluripotency. Exactly how LIF/Stat3 signaling...

...Frederick Anokye-Danso; Melinda Snitow; Edward E. Morrisey Summary The ability to generate pluripotent stem cells from a variety of cell and tissue sources through the ectopic expression of a specific set of transcription factors has revolutionized regenerative biology. The development...

...-like phenotypes in human dental pulp from the third molar. In the present work, we describe a new population of dental pulp pluripotent-like stem cells (DPPSCs) that were isolated by culture in medium containing LIF, EGF and PDGF. These cells are SSEA4 + , OCT3/4 + , NANOG + , SOX2 + , LIN28 + , CD13...

... transition from hESCs to more quiescent somatic cell types, and supports important roles for mitochondria and secretion in hESC biology. Mitochondria Pluripotency Embryonic stem cells Neural stem cells Differentiation Secretion © 2011. 2011 10 10 2010 * Author...

...Jeong Tae Do; Dong Wook Han; Luca Gentile; Ingeborg Sobek-Klocke; Anton Wutz; Hans R. Schöler The fusion of somatic cells with pluripotent cells results in the generation of pluripotent hybrid cells. Because the `memory' of somatic cells seems to be erased during fusion-induced reprogramming...

...Emmajayne Kingham; Melanie Welham Self-renewal of embryonic stem cells (ESCs) is essential for maintenance of pluripotency, which is defined as the ability to differentiate into any specialised cell type comprising the adult organism. Understanding the mechanisms that regulate ESC self-renewal...

...Ludovic Vallier; Morgan Alexander; Roger A. Pedersen Maintenance of pluripotency is crucial to the mammalian embryo's ability to generate the extra-embryonic and embryonic tissues that are needed for intrauterine survival and foetal development. The recent establishment of embryonic stem cells from...