...John F. Martin; Pier Paolo D'Avino ABSTRACT Platelets are found only in mammals. Uniquely, they have a log Gaussian volume distribution and are produced from megakaryocytes, large cells that have polyploid nuclei. In this Hypothesis, we propose that a possible explanation for the origin...

.... Mechanistically, paxillin, together with kindlin, was able to promote the binding of the talin head domain to integrin, suggesting that paxillin complexes with kindlin and talin to strengthen integrin activation. Specifically, we observed that crosstalk between kindlin-3 and the paxillin family in mouse platelets...

...Sarah Schwarz Henriques; Rabea Sandmann; Alexander Strate; Sarah Köster Summary Contraction at the cellular level is vital for living organisms. The most prominent type of contractile cells are heart muscle cells, a less-well-known example is blood platelets. Blood platelets activate and interlink...

...Stéphane Bodin; Carine Soulet; Hélène Tronchère; Pierre Sié; Christian Gachet; Monique Plantavid; Bernard Payrastre Dynamic connections between actin filaments and the plasma membrane are crucial for the regulation of blood platelet functions. Protein complexes associated with αIIbβ3 integrin...

...Fern Tablin; Miriam J. Reeber; Vivianne T. Nachmias ABSTRACT We have demonstrated the presence of a 210K (K= 10 3 M r ) microtubule-associated protein (MAP) in blood platelets and have studied its relationship to tubulin and to the cytoskeleton, using a well-characterized polyclonal antibody...

...H. Tamir; R. F. Payette; Y. L. Huang; K. P. Liu; M. D. Gershon ABSTRACT A glycoprotein that circulates in blood, binds to the surface of platelets, and also binds serotonin with high avidity and specificity, has previously been found in rats. This glycoprotein has been called serotonectin. We now...