...Hidetaka Uramoto; Daniel Wetterskog; Anders Hackzell; Yoshiki Matsumoto; Keiko Funa We investigated mechanisms of the p73α-mediated repression of the platelet-derived growth factor β-receptor (PDGFRB) promoter caused by its interaction with NF-Y. Treatment of cells with the histone deacetylase...

... 17 3 2004 © The Company of Biologists Limited 2004 2004 Platelet-derived growth factor β-receptor SV40LT pRb c-Myc p53 Platelet-derived growth factor (PDGF) is a serum mitogen consisting of four isoforms: A, B, C and D. These isoforms exist as dimers: AA, BB, AB, CC and DD...

...Antonella Puglianiello; Luisa Campagnolo; Donatella Farini; Daria Cipollone; Mario A. Russo; Gregorio Siracusa The role played by PDGF in testis morphogenesis is still incompletely understood. The present study investigates the expression and potential role of platelet-derived growth factor-BB...

...), insulin, platelet-derived growth factor, and hepatocyte growth factor), bFGF, IGF-1 and EGF enhanced [ 3 H]glutamate transport activity in a concentration-dependent manner. These effects were accompanied by an increase in the V max value for transport activity and in GLAST protein and mRNA levels, which...

...Hiroto Izumi; Catrin Molander; Linda Z. Penn; Akira Ishisaki; Kimitoshi Kohno; Keiko Funa ABSTRACT c-Myc plays a key role in the cell cycle dependent control of the PDGF β-receptor mRNA. The mouse platelet-derived growth factor (PDGF) β-receptor promoter contains a CCAAT motif, and NF-Y plays...

... on a plastic substratum, cultured RPE cells mimic the proliferating phenotype in situ; they escape density arrest and proliferate in serum-free medium. In this study, we have demonstrated that a platelet-derived growth factor (PDGF) autocrine loop is involved in RPE growth in serum-free medium, because: (1...

...Anders Tingström; Carl-Henrik Heldin; Kristofer Rubin ABSTRACT We have examined the effects of three macrophage-derived cytokines, platelet-derived growth factor (PDGF), transforming growth factor- β 1 (TGF- β 1) and interleukin-la (IL-1 a) on the contraction of collagen type I gels populated...

...Johan Thyberg; Arne Östman; Gudrun Bäckström; Bengt Westermark; Carl-Henrik Heldin ABSTRACT Platelet-derived growth factor (PDGF) is a powerful mitogen for connective tissue cells. It is made up of two polypeptide chains (A and B) and exists in three dimeric forms (AA, AB, and BB). Transfection...

...William J. Larochelle; Neill Giese; Mary May-Siroff; Keith C. Robbins; Stuart A. Aaronson ABSTRACT Human platelet-derived growth factor (PDGF) is a connective tissue cell mitogen comprising two related chains encoded by distinct genes. The B chain is the homolog of the v-sis oncogene product...