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Keywords: Plasma membrane
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Journal Articles
J Cell Sci (2019) 132 (15): jcs232132.
Published: 31 July 2019
...Lingxiao Tan; Kwang-Jin Cho; Walaa E. Kattan; Christian M. Garrido; Yong Zhou; Pratik Neupane; Robert J. Capon; John F. Hancock ABSTRACT The primary site for KRAS signaling is the inner leaflet of the plasma membrane (PM). We previously reported that oxanthroquinone G01 (G01) inhibited KRAS PM...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (2): jcs203828.
Published: 29 January 2018
... plasma membrane (PM). Distinct PM AGD1-GFP signal was first detected along the site of root hair bulge formation. The construct continued to mark the PM at the root hair apical dome, but only during periods of reduced growth. During rapid tip growth, AGD1-GFP labeled the PM of the lateral flanks...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (20): 3437–3445.
Published: 15 October 2017
... that are apposed to the plasma membrane. They form a rim of filaments interconnecting the desmosomes in a circumferential network. We hypothesize that they are part of a rim-and-spoke arrangement of IFs in epithelia. From our review of the literature, we extend this functional role for the subplasmalemmal rim...
Journal Articles
J Cell Sci (2016) 129 (4): 673–680.
Published: 15 February 2016
..., into the blood stream. Before release, the final step of merozoite development is the assembly of the cortical pellicle, a multi-layered membrane structure. This unique apicomplexan feature includes the inner membrane complex (IMC) and the parasite's plasma membrane. A dynamic ring structure, referred...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (1): 95–107.
Published: 01 January 2016
...Tomáš Chum; Daniela Glatzová; Zuzana Kvíčalová; Jan Malínský; Tomáš Brdička; Marek Cebecauer ABSTRACT Plasma membrane proteins synthesised at the endoplasmic reticulum are delivered to the cell surface via sorting pathways. Hydrophobic mismatch theory based on the length of the transmembrane domain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (22): 4057–4062.
Published: 15 November 2015
...Ruth Kabeche; Louisa Howard; James B. Moseley ABSTRACT Cell surface area rapidly increases during mechanical and hypoosmotic stresses. Such expansion of the plasma membrane requires ‘membrane reservoirs' that provide surface area and buffer membrane tension, but the sources of this membrane remain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (22): 4220–4234.
Published: 15 November 2015
...Derek C. Prosser; Anthony E. Pannunzio; Jeffrey L. Brodsky; Jeremy Thorner; Beverly Wendland; Allyson F. O'Donnell ABSTRACT Clathrin-mediated endocytosis (CME) is a well-studied mechanism to internalize plasma membrane proteins; however, to endocytose such cargo, most eukaryotic cells also use...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (8): 1627–1638.
Published: 15 April 2015
... released from thrombin‐activated platelets lost membrane asymmetry. Our results suggest that the microparticles were shed from platelet plasma membrane domains enriched with phosphatidylserine and/or phosphatidylinositol at the outer leaflet. These findings underscore the strict regulation and cell‐type...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (7): 1422–1433.
Published: 01 April 2015
...Masashi Maekawa; Gregory D. Fairn ABSTRACT Cholesterol is an essential component of metazoan cellular membranes and it helps to maintain the structural integrity and fluidity of the plasma membrane. Here, we developed a cholesterol biosensor, termed D4H, based on the fourth domain of Clostridium...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (1): 61–69.
Published: 01 January 2015
...Saori Yamauchi; Keisuke Obara; Kenya Uchibori; Akiko Kamimura; Kaoru Azumi; Akio Kihara ABSTRACT Plasma membrane lipid asymmetry is important for various membrane-associated functions and is regulated by membrane proteins termed flippases and floppases. The Rim101 pathway senses altered lipid...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (23): 4995–5005.
Published: 01 December 2014
...Maria F. Garcia-Parajo; Alessandra Cambi; Juan A. Torreno-Pina; Nancy Thompson; Ken Jacobson ABSTRACT Early studies have revealed that some mammalian plasma membrane proteins exist in small nanoclusters. The advent of super-resolution microscopy has corroborated and extended this picture, and led...
Journal Articles
J Cell Sci (2014) 127 (19): 4103–4109.
Published: 01 October 2014
.... These effectors function in vesicle formation and tethering, non-vesicular lipid transport and cytoskeletal regulation. Beyond fundamental membrane trafficking roles, Arf proteins also regulate mitosis, plasma membrane signaling, cilary trafficking and lipid droplet function. Tight spatial and temporal regulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5681–5691.
Published: 15 December 2013
... in leukocytes and sensory neuron contributes to the pathophysiology of autoimmune diseases and sensory syndromes. Molecular mechanisms underlying Kv1.3 channel trafficking to the plasma membrane remain elusive. We report a novel non-canonical di-acidic signal (E483/484) at the C-terminus of Kv1.3 essential...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (20): 4746–4755.
Published: 15 October 2013
... of an intracellular FLT3-ITD/Ras signaling pathway by comparing Ras signaling of FLT3 ITD with that of wild-type FLT3. Ligand stimulation activated both K- and N-Ras in cells expressing wild-type FLT3. Live-cell Ras–GTP imaging revealed ligand-induced Ras activation at the plasma membrane (PM). FLT3-ITD-dependent...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (14): 2990–2996.
Published: 15 July 2013
..., but was instead SipB and cholesterol dependent. Thus, we measured the levels of plasma membrane and cell surface cholesterol throughout the cell cycle using, respectively, brief staining with filipin and a fluorescent ester of polyethylene glycol-cholesterol that cannot flip through the plasma membrane, and found...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (5): 1227–1234.
Published: 01 March 2013
... order in both high-GP and low-GP regions ( Fig. 3E ). These findings suggest that the lipid order response to shear stress occurs in artificial membranes as well as in the plasma membranes of living cells. In flow-loading experiments, ECs are subjected not only to shear stress but to pressure...
Journal Articles
J Cell Sci (2010) 123 (13): 2218–2227.
Published: 01 July 2010
... and Schweizer, 1975 ; Stukey et al., 1989 ). From studies in animal cells, four different proteins have been implicated in fatty-acid uptake: the fatty-acid transport proteins (FATPs) ( Watkins, 2008 ), the class B scavenger receptor FAT (also known as CD36) ( Febbraio et al., 2001 ), the plasma-membrane...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (5): 671–681.
Published: 01 March 2010
... of the plasma membrane, underlies pGal-3-induced axon branching, and that galectin phosphorylation in situ could act as a molecular switch for the axon response to Gal-3. The formation of a new branch requires local cytoskeleton remodelling to determine its location as well as to trigger and maintain its...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (5): 625–635.
Published: 01 March 2009
... of the plasma membrane. Transport of IST2 mRNA and local protein synthesis are not prerequisite for this localisation, indicating that Ist2 can travel through the general ER to membranes at the cell periphery. Here, we describe that the accumulation of Ist2 at the cortical ER requires a cytosolically exposed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (5): 634–643.
Published: 01 March 2008
... lateral distribution in the plasma membrane of dendritic cells and other cells: the receptor is preferentially localized to the leading edge of the dendritic cell lamellipod and largely excluded from the ventral plasma membrane. Colocalization of DC-SIGN clusters with endocytic activity demonstrated...
Includes: Multimedia, Supplementary data