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Keywords: Plakophilin
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Journal Articles
J Cell Sci jcs.258906.
Published: 12 October 2021
... and mechanically integrate cells across tissues, dissipating mechanical stress. They comprise five major protein classes – desmocollins and desmogleins (the desmosomal cadherins), plakoglobin, plakophilins and desmoplakin - whose individual contribution to the structure and turnover of desmosomes is poorly...
Journal Articles
J Cell Sci (2018) 131 (10): jcs212191.
Published: 22 May 2018
... signaling regulates the phosphorylation-dependent association of plakophilins 1 and 3 (PKP1 and PKP3) with 14-3-3 protein isoforms, and uncover unique and partially antagonistic functions of members of the 14-3-3 family in the regulation of desmosomes. 14-3-3γ associated primarily with cytoplasmic PKP1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (17): 3782–3793.
Published: 01 September 2014
... with a host of desmosomal plaque proteins, including plakophilins, plakoglobin and desmoplakin, which, in turn, recruit the intermediate filament cytoskeleton to sites of cell–cell contact. Although the individual components of the desmosome are known, mechanisms regulating the assembly of this junction...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (8): 1832–1844.
Published: 15 April 2013
... formation by regulating the balance between adhesion and proliferation is not well understood. The desmosomal protein plakophilin 1 can increase intercellular adhesion by recruiting desmosomal proteins to the plasma membrane or stimulate proliferation by enhancing translation rates. Here, we show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (12): 2126–2136.
Published: 15 June 2007
... between αT-catenin and plakophilins was observed and subsequently confirmed by co-immunoprecipitation and colocalization. Interaction with the amino-terminal part of plakophilins appeared to be specific for the central `adhesion-modulation' domain of αT-catenin. In addition, we showed, by immuno-electron...
Journal Articles
J Cell Sci (2006) 119 (5): 797–806.
Published: 01 March 2006
... in epidermal morphogenesis. The desmosomal cadherin-plakoglobin complex is coupled to the intermediate filament network by desmoplakin, a member of the plakin family of cytolinkers ( Leung et al., 2001 ; Leung et al., 2002 ). The N-terminal domain of desmoplakin binds to plakoglobin and plakophilin...
Journal Articles
J Cell Sci (2003) 116 (7): 1219–1233.
Published: 01 April 2003
...Mechthild Hatzfeld; Kathleen J. Green; Helmut Sauter p0071, a member of the armadillo protein family, is most closely related to p120 ctn and the plakophilins 1-3. Whereas plakophilins are desmosomal plaque proteins, p120 ctn localizes to adherens junctions and interacts with classical cadherins...