... possesses an essential polycystin homologue, Pkd2, which directs Ca 2+ influx on the cell surface in response to membrane tension, but its structure remains unsolved. Here, we analyzed the structure–function relationship of Pkd2 based on its AlphaFold-predicted structure. Pkd2 consists of three domains...

... membrane-localized fission yeast polycystin homolog Pkd2p is an essential protein required for cytokinesis; however, its role remains unclear. Here, we isolated a novel temperature-sensitive pkd2 mutant, pkd2-B42 . Among the strong growth defects of this mutant, the most striking was that many mutant cells...

...; Christine Ziegler; Silke Haerteis; Christoph Korbmacher; Ralph Witzgall ABSTRACT Mutations in the PKD2 gene cause autosomal-dominant polycystic kidney disease but the physiological role of polycystin-2, the protein product of PKD2 , remains elusive. Polycystin-2 belongs to the transient receptor potential...

... to enhance vesicle fission by modifying the lipid environment. PKD also phosphorylates the actin regulatory protein cortactin at S298 to impair synergistic actin polymerization. We here report additional functions for PKD2 (also known as PRKD2) and cortactin in the regulation of actin polymerization during...