...Maria Sharkova; Gonzalo Aparicio; Constantin Mouzaaber; Flavio R. Zolessi; Jennifer C. Hocking ABSTRACT Vertebrate photoreceptors detect light through a large cilium-based outer segment, which is filled with photopigment-laden membranous discs. Surrounding the base of the outer segment...

... development in two models of embryonic hyperglycemia in zebrafish. Strikingly, we found that hyperglycemic larvae displayed a significant reduction in photoreceptors and horizontal cells, whereas other retinal neurons were not affected. We also observed reactive gliosis and abnormal optokinetic responses...

... mechanisms of polarized transport have not been elucidated. Drosophila photoreceptor offers an excellent model for studying this. We found that Rab10 impairment significantly reduced basolateral levels of Na + K + ATPase, mislocalizing it to the stalk membrane, which is a domain of the apical plasma membrane...

...Robert S. Molday; Orson L. Moritz ABSTRACT Retinal photoreceptor cells contain a specialized outer segment (OS) compartment that functions in the capture of light and its conversion into electrical signals in a process known as phototransduction. In rods, photoisomerization of 11- cis to all- trans...

...Jonathan A. Coleman; Xianjun Zhu; Hidayat R. Djajadi; Laurie L. Molday; Richard S. Smith; Richard T. Libby; Simon W. M. John; Robert S. Molday ABSTRACT ATP8A2 is a P 4 -ATPase that is highly expressed in the retina, brain, spinal cord and testes. In the retina, ATP8A2 is localized in photoreceptors...

...Christiana L. Cheng; Robert S. Molday Summary In photoreceptors, the assembly of signaling molecules into macromolecular complexes is important for phototransduction and maintaining the structural integrity of rod outer segments (ROSs). However, the molecular composition and formation...

...Prachee Avasthi; Jan Frederik Scheel; Guoxin Ying; Jeanne M. Frederick; Wolfgang Baehr; Uwe Wolfrum Summary Centrins are calmodulin-like Ca 2+ -binding proteins that can be found in all ciliated eukaryotic cells from yeast to mammals. Expressed in male germ cells and photoreceptors, centrin 1...

... in the retinae of mice lacking Cplx3 and Cplx4, with a significant proportion of photoreceptor terminals containing spherical free-floating ribbons. These structural and functional aberrations were accompanied by behavioural deficits indicative of a vision deficit. Our results show that Cplx3 and Cplx4...

...Jennifer Lin-Jones; Ed Parker; Mike Wu; Andréa Dosé; Beth Burnside Myo3A, a class III myosin, localizes to the distal (plus) ends of inner segment actin filament bundles that form the core of microvillus-like calycal processes encircling the base of the photoreceptor outer segment. To investigate...

...Jun-Hai Yang; Ronald L. Gross; Scott F. Basinger; Samuel M. Wu ABSTRACT Photoreceptor degeneration is mediated by apoptosis in several animal models, although the underlying mechanisms are yet to be elucidated. We present here an apoptotic model based on a primary cell culture of tiger salamander...