..., highlighting the requirement for host cell factors in viral particle assembly and budding. HIV-1 Gag Membrane curvature Phospholipids Cortical actin SIDACTION http://dx.doi.org/10.13039/100009060 National Agency for AIDS Research http://dx.doi.org/10.13039/501100003323...

...Alaumy Joshi; Travis H. Richard; Vishal M. Gohil ABSTRACT Studies of rare human genetic disorders of mitochondrial phospholipid metabolism have highlighted the crucial role that membrane phospholipids play in mitochondrial bioenergetics and human health. The phospholipid composition...

... is additionally involved in phospholipid homeostasis. Moreover, overexpression of CQD1 and CQD2 causes tethering of mitochondria to the endoplasmic reticulum, which might explain the ability of Cqd2 to rescue ERMES deletion phenotypes. * Deceased ‡ Author for correspondence ( [email protected]...

... of the phosphoinositide 5′-phosphatase gene Inpp5e , mutation of which is causative of Joubert syndrome, in terminally developed mouse olfactory sensory neurons (OSNs), leads to a dramatic remodeling of ciliary phospholipids that is accompanied by marked elongation of cilia. Phosphatidylinositol (4,5)-bisphosphate [PI...

... phospholipid hydroperoxides, particularly hydroperoxyl (Hp) forms of arachidonoyl- and adrenoyl-phosphatidylethanolamine, with a downstream cascade of oxidative damage to membrane lipids, proteins and DNA, culminating in cell death. We recently showed that human trophoblasts are particularly sensitive...

... perturbation, independently of misfolded proteins. Comprising primarily phospholipids, sphingolipids and sterols, individual membranes can contain hundreds of distinct lipids. Even with such complexity, lipid distribution in a cell is tightly regulated by mechanisms that remain incompletely understood...

... Summary: A review of the current knowledge of the timeline of clathrin-mediated endocytosis in the budding yeast S . cerevisiae , including discussion of recent works that focus on how this process is regulated. Saccharomyces cerevisiae Actin Clathrin-mediated endocytosis Phospholipids...

..., we have identified enzymes that are involved in phospholipid metabolism. Loss of the phospholipid methyltransferase Cho2p, which showed the strongest impact on mRNA localization, disturbs mRNA localization, as well as ER morphology and segregation, owing to an increase in the amount of cellular...

... the invasive growth defect of mss4-f12 cells. Taken together, our results indicate that plasma membrane PtdIns(4,5) P 2 is crucial for yeast invasive growth and suggest that this phospholipid functions upstream of the cAMP-dependent protein kinase A signaling pathway. * Present address: Université...

... in phospholipids. Together, our findings demonstrate that VLCFA-containing lipids are essential for endomembrane dynamics during cytokinesis. References Al-Feel W. , DeMar J. C. , Wakil S. J. ( 2003 ). A Saccharomyces cerevisiae mutant strain defective in acetyl-CoA carboxylase arrests...

... is known about the regulation of this process. Here we have examined binding of radiolabeled and fluorescently labeled liposomes to schistosomula, and followed incorporation of fluorescent phospholipids into the worm by both morphological and biochemical methods. Saturable binding of radiolabeled...