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Keywords: Phospholipase D
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Journal Articles
J Cell Sci (2014) 127 (14): 3104–3115.
Published: 15 July 2014
... stimulates lipid droplet formation by activating the long-chain fatty acid receptor FFAR4, which signals through a pertussis-toxin-sensitive G-protein signalling pathway involving phosphoinositide 3-kinase (PI3-kinase), AKT (also known as protein kinase B) and phospholipase D (PLD) activities. This initial...
Journal Articles
J Cell Sci (2012) 125 (12): 3004–3011.
Published: 15 June 2012
... of phosphatidylinositol phosphates, which in turn activate the phospholipase D, Spo14; (2) is required for a late step in cytokinesis that gives rise to spores; and (3) regulates a membrane-bending activity that generates intralumenal vesicles. These results demonstrate that Vps13 plays a broader role in membrane biology...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (12): 1973–1983.
Published: 15 June 2011
... by phospholipase D (PLD) enzymes. Neutrophils, important cells of the innate immune system, maintain the body's defence against infection. Previous studies have implicated PLD-generated PA in neutrophil function; these have relied heavily on the use of primary alcohols to act as inhibitors of PA production...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (3): 407–416.
Published: 01 February 2007
... synthesis promoted myogenesis by removing this control. Phospholipase D (PLD), a recognized target of ceramide, is required for myogenesis, as shown by the negative effects of PLD1 isoform depletion obtained by siRNA treatment. Fumonisin induced an increase in PLD activity of L6 cells, whereas C6-ceramide...
Journal Articles
J Cell Sci (2006) 119 (8): 1645–1654.
Published: 15 April 2006
...Abigail R. Mazie; Julie K. Spix; Ethan R. Block; Hewa B. Achebe; Jes K. Klarlund Phospholipase D catalyzes the hydrolysis of phosphatidylcholine to generate phosphatidic acid, and there is currently much interest in elucidating messenger functions for this molecule. We report here that wounding...
Journal Articles
J Cell Sci (2006) 119 (7): 1406–1415.
Published: 01 April 2006
... of the spindle pole body. Spo14p, the major yeast phospholipase D, is necessary for prospore membrane formation; however, the specific function of Spo14p in this process has not been elucidated. We report that loss of Spo14p blocks vesicle fusion, leading to the accumulation of prospore membrane precursor...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (19): 4365–4375.
Published: 01 September 2004
... phosphatidylinositol (3,4,5)-trisphosphate endocytic recycling compartment Phosphatidic acid Phospholipase D Rab11 is a small GTPase that plays a role in regulating membrane traffic from the endocytic recycling compartment (ERC) to either the plasma membrane or the trans-Golgi network (TGN). Recently...
Journal Articles
J Cell Sci (2003) 116 (15): 3177–3187.
Published: 01 August 2003
... by n-butanol, which prevents phosphatidic acid production by phospholipase D, but not by t-butanol, which does not prevent phosphatidic acid production. These results and previously reported effects of short-chain ceramides on phospholipase D activity prompted us to compare the effects of C 2 -ceramide...