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Keywords: Phosphoinositides
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Journal Articles
In collection:
Mitochondria
J Cell Sci (2022) 135 (5): jcs259073.
Published: 16 December 2021
...+ is the most important trigger of insulin secretion, but the response can also be modulated by many factors, including lipids and lipid-derived signaling molecules. Phosphoinositides in particular have been shown to regulate insulin secretion at several stages, including membrane depolarization, Ca 2+ influx...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (5): jcs259365.
Published: 22 October 2021
...-cysteine motif in EFR3B (Cys5, Cys7 and Cys8) in controlling the distribution of PI4KIIIα between these two complexes at the plasma membrane and corresponding functions in phosphoinositide homeostasis. Spacing of palmitoyl groups within three doubly palmitoylated EFR3B ‘lipoforms’ affects both interactions...
Includes: Supplementary data
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2020) 133 (23): jcs247973.
Published: 3 December 2020
...Chloe E. Snider; Alaina H. Willet; HannahSofia T. Brown; Jun-Song Chen; Joshua M. Evers; Kathleen L. Gould ABSTRACT Phosphoinositides (PIPs) are a dynamic family of lipids that execute diverse roles in cell biology. PIP levels are regulated by numerous enzymes, but our understanding of how...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (6): jcs237388.
Published: 16 March 2020
...Gergő Gulyás; Mira Sohn; Yeun Ju Kim; Péter Várnai; Tamas Balla ABSTRACT Oxysterol-binding protein (OSBP)-related proteins (ORPs) mediate non-vesicular lipid transfer between intracellular membranes. Phosphoinositide (PI) gradients play important roles in the ability of OSBP and some ORPs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (2): jcs233254.
Published: 23 January 2020
...Lizbeth de la Cruz; Alexis Traynor-Kaplan; Oscar Vivas; Bertil Hille; Jill B. Jensen ABSTRACT Phosphoinositide lipids regulate many cellular processes and are synthesized by lipid kinases. Type I phosphatidylinositol phosphate 5-kinases (PIP5KIs) generate phosphatidylinositol 4,5-bisphosphate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (10): jcs213587.
Published: 21 May 2018
... , R. J. ( 2016 ). Phagocytosis enhances lysosomal and bactericidal properties by activating the transcription factor TFEB . Curr. Biol.   26 , 1955 - 1964 . 10.1016/j.cub.2016.05.070 Han , B.-K. and Emr , S. D. ( 2011 ). Phosphoinositide [PI(3,5)P2] lipid-dependent regulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (8): jcs211094.
Published: 13 April 2018
... . MRS Bull.   37 , 53 - 62 . 10.1557/mrs.2011.329 Balla , T. ( 2013 ). Phosphoinositides: tiny lipids with giant impact on cell regulation . Physiol. Rev.   93 , 1019 - 1137 . 10.1152/physrev.00028.2012 Bendayan , M. ( 1981 ). Ultrastructural localization of nuclei acids...
Includes: Supplementary data
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2018) 131 (1): jcs207985.
Published: 8 January 2018
... of Biologists Ltd 2018 http://www.biologists.com/user-licence-1-1/ Summary: FFA–VAP interactions regulate lipid transfer activity in Drosophila photoreceptors during PLC signalling. Drosophila FFAT–VAP Lipid transfer Membrane contact site Phosphoinositides An essential feature...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2017) 130 (7): 1209–1216.
Published: 1 April 2017
.... Phosphoinositides Autophagy Fusion Lysosome More than 60 SNAREs determine membrane fusion specificity and drive the fusion processes of mammalian cells. Functionally, SNAREs are grouped into v-SNAREs on donor vesicles and t-SNAREs on target vesicles. Structurally, SNAREs are divided into Q-SNAREs (which...
Journal Articles
J Cell Sci (2017) 130 (2): 444–452.
Published: 15 January 2017
... the formation of both pronuclear and zygote nuclear envelopes in the fertilised egg. Here, we determine that class-I phosphoinositide 3-kinases (PI3Ks) are needed for in vitro nuclear envelope formation. We show that, in vivo , PtdIns(3,4,5) P 3 is transiently located in vesicles around the male pronucleus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (4): 815–827.
Published: 15 February 2015
...Frédéric Boal; Rana Mansour; Marion Gayral; Estelle Saland; Gaëtan Chicanne; Jean-Marie Xuereb; Marlène Marcellin; Odile Burlet-Schiltz; Philippe J. Sansonetti; Bernard Payrastre; Hélène Tronchère ABSTRACT Phosphoinositides represent a major class of lipids specifically involved in the organization...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (2): 593–604.
Published: 15 January 2013
...). Atg18 is essential for autophagy but also for vacuole homeostasis and probably endosomal functions. This protein is basically a β-propeller, formed by seven WD40 repeats, that contains a conserved FRRG motif that binds to phosphoinositides and promotes Atg18 recruitment to the PAS, endosomes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (9): 2185–2197.
Published: 1 May 2012
...   J. G. , Falck   J. R. , Benovic   J. L. , Keen   J. H. ( 1999 ). Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding . EMBO J.   18 , 871 - 881 . Goh   L. K. , Huang   F. , Kim   W. , Gygi   S. , Sorkin   A. ( 2010...
Includes: Multimedia, Supplementary data
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2008) 121 (12): 1955–1963.
Published: 15 June 2008
...Giovanni D'Angelo; Mariella Vicinanza; Antonella Di Campli; Maria Antonietta De Matteis The phosphoinositides (PIs) are membrane phospholipids that actively operate at membrane-cytosol interfaces through the recruitment of a number of effector proteins. In this context, each of the seven different...
Journal Articles
J Cell Sci (2008) 121 (9): 1488–1494.
Published: 1 May 2008
.... Although phosphoinositides represent a minor fraction of cellular phospholipids, they are integral components of membranes and are believed to play key roles in cell signaling, cytoskeletal organization, vesicular transport and ion-channel regulation ( Di Paolo and De Camilli, 2006 ; Suh and Hille, 2005...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (7): 1076–1084.
Published: 1 April 2008
... are assembled, the signals that initiate axoneme outgrowth remain unknown. Here, we identified phosphatidylinositol phosphates (phosphoinositides) as key regulators of early stages of axoneme outgrowth in Drosophila melanogaster spermatogenesis. In a study of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5) P...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (19): 4405–4413.
Published: 1 October 2005
... examined the properties of the PX domains of PLD1 and PLD2 in terms of phosphoinositide binding and PLD activity regulation. Interestingly, the PX domain of PLD1, but not that of PLD2, was found to specifically interact with phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5) P 3 ). We found...
Journal Articles
J Cell Sci (2005) 118 (9): 2005–2012.
Published: 1 May 2005
...Óscar Lorenzo; Sylvie Urbé; Michael J. Clague The myotubularins are a large family of phosphoinositide-specific phosphatases with substrate specificity for PtdIns3 P and PtdIns(3,5) P 2 . In addition to an N-terminal PH-GRAM (PH-G) domain and a signature catalytic domain shared with other family...
Journal Articles
J Cell Sci (2005) 118 (7): 1373–1384.
Published: 1 April 2005
...Plamen Georgiev; Isaac Garcia-Murillas; Danny Ulahannan; Roger C. Hardie; Padinjat Raghu The TRP family of ion channels mediates a wide range of calcium-influx phenomena in eukaryotic cells. Many members of this family are activated downstream of phosphoinositide hydrolysis but the subsequent steps...
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2005) 118 (4): 759–769.
Published: 15 February 2005
... phase of platelet activation. * Author for correspondence (e-mail: payrastr@toulouse.inserm.fr ) 16 11 2004 © The Company of Biologists Limited 2005 2005 Platelets Lipid rafts Actin Cytoskeleton Integrins Phosphoinositides Platelets (2×10 9 cells/ml) were lysed...