... and APOE-ε4 iPSC-derived neurons, which are recapitulated by neuronal PIKfyve inhibition and remediated by the TRPML1 agonist ML-SA1. Alzheimer's disease TRPML1 Ca 2+ APOE PIKfyve Phosphoinositides Science Foundation Ireland http://dx.doi.org/10.13039/501100001602 SFI15/COEN/3037...

... sites Ca 2+ Insulin secretion Phosphoinositides Mitochondria Novo Nordisk Fonden http://dx.doi.org/10.13039/501100009708 NNF19OC0055275 Vetenskapsrådet http://dx.doi.org/10.13039/501100004359 2019-01456 Åke Wibergs Stiftelse M18-0146 Diabetesfonden...

...-cysteine motif in EFR3B (Cys5, Cys7 and Cys8) in controlling the distribution of PI4KIIIα between these two complexes at the plasma membrane and corresponding functions in phosphoinositide homeostasis. Spacing of palmitoyl groups within three doubly palmitoylated EFR3B ‘lipoforms’ affects both interactions...

...Chloe E. Snider; Alaina H. Willet; HannahSofia T. Brown; Jun-Song Chen; Joshua M. Evers; Kathleen L. Gould ABSTRACT Phosphoinositides (PIPs) are a dynamic family of lipids that execute diverse roles in cell biology. PIP levels are regulated by numerous enzymes, but our understanding of how...

...Gergő Gulyás; Mira Sohn; Yeun Ju Kim; Péter Várnai; Tamas Balla ABSTRACT Oxysterol-binding protein (OSBP)-related proteins (ORPs) mediate non-vesicular lipid transfer between intracellular membranes. Phosphoinositide (PI) gradients play important roles in the ability of OSBP and some ORPs...

...Lizbeth de la Cruz; Alexis Traynor-Kaplan; Oscar Vivas; Bertil Hille; Jill B. Jensen ABSTRACT Phosphoinositide lipids regulate many cellular processes and are synthesized by lipid kinases. Type I phosphatidylinositol phosphate 5-kinases (PIP5KIs) generate phosphatidylinositol 4,5-bisphosphate...

... in fewer, enlarged lysosomes; TFEB-mediated lysosome biosynthesis does not contribute to swelling. Transcription factors Phosphoinositides Lysosomes Organelles Fusion Fission Natural Sciences and Engineering Research Council of Canada 10.13039/501100000038 Government...

... transcription Chromatin RNA polymerase II Phosphoinositides Czech Science Foundation 10.13039/501100001824 GAP305/11/2232 GA16-03346S GA15-08738S Technology Agency of the Czech Republic TE01020118 Human Frontier Science Program 10.13039/100004412 RGP0017/2013...

... of Biologists Ltd 2018 http://www.biologists.com/user-licence-1-1/ Summary: FFA–VAP interactions regulate lipid transfer activity in Drosophila photoreceptors during PLC signalling. Drosophila FFAT–VAP Lipid transfer Membrane contact site Phosphoinositides National Centre...

....2009.00082.x Nakamura , S. , Hasegawa , J. and Yoshimori , T. ( 2016 ). Regulation of lysosomal phosphoinositide balance by INPP5E is essential for autophagosome-lysosome fusion . Autophagy   12 , 2500 - 2501 . 10.1080/15548627.2016.1234568 Nguyen , T. N. , Padman , B...

... the formation of both pronuclear and zygote nuclear envelopes in the fertilised egg. Here, we determine that class-I phosphoinositide 3-kinases (PI3Ks) are needed for in vitro nuclear envelope formation. We show that, in vivo , PtdIns(3,4,5) P 3 is transiently located in vesicles around the male pronucleus...

...Frédéric Boal; Rana Mansour; Marion Gayral; Estelle Saland; Gaëtan Chicanne; Jean-Marie Xuereb; Marlène Marcellin; Odile Burlet-Schiltz; Philippe J. Sansonetti; Bernard Payrastre; Hélène Tronchère ABSTRACT Phosphoinositides represent a major class of lipids specifically involved in the organization...

...). Atg18 is essential for autophagy but also for vacuole homeostasis and probably endosomal functions. This protein is basically a β-propeller, formed by seven WD40 repeats, that contains a conserved FRRG motif that binds to phosphoinositides and promotes Atg18 recruitment to the PAS, endosomes...

... efficiently and hence cannot reach the early endosomal compartment. * Author for correspondence ( [email protected] ) 22 12 2011 © 2012. 2012 Bioluminescence resonance energy transfer Endocytosis G-protein-coupled receptors Phosphoinositides Cell surface receptors...

...Giovanni D'Angelo; Mariella Vicinanza; Antonella Di Campli; Maria Antonietta De Matteis The phosphoinositides (PIs) are membrane phospholipids that actively operate at membrane-cytosol interfaces through the recruitment of a number of effector proteins. In this context, each of the seven different...

.... * Author for correspondence (e-mail: [email protected] ) 21 2 2008 © The Company of Biologists Limited 2008 2008 Endocytosis Phosphoinositides Recycling Although phosphoinositides represent a minor fraction of cellular phospholipids, they are integral components...

... are assembled, the signals that initiate axoneme outgrowth remain unknown. Here, we identified phosphatidylinositol phosphates (phosphoinositides) as key regulators of early stages of axoneme outgrowth in Drosophila melanogaster spermatogenesis. In a study of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5) P...

... examined the properties of the PX domains of PLD1 and PLD2 in terms of phosphoinositide binding and PLD activity regulation. Interestingly, the PX domain of PLD1, but not that of PLD2, was found to specifically interact with phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5) P 3 ). We found...

...Óscar Lorenzo; Sylvie Urbé; Michael J. Clague The myotubularins are a large family of phosphoinositide-specific phosphatases with substrate specificity for PtdIns3 P and PtdIns(3,5) P 2 . In addition to an N-terminal PH-GRAM (PH-G) domain and a signature catalytic domain shared with other family...

...Plamen Georgiev; Isaac Garcia-Murillas; Danny Ulahannan; Roger C. Hardie; Padinjat Raghu The TRP family of ion channels mediates a wide range of calcium-influx phenomena in eukaryotic cells. Many members of this family are activated downstream of phosphoinositide hydrolysis but the subsequent steps...