1-16 of 16
Keywords: Phosphoinositide 3-kinase
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
J Cell Sci (2021) 134 (3): jcs246090.
Published: 10 February 2021
...Fatemeh Mazloumi Gavgani; Thomas Karlsson; Ingvild L. Tangen; Andrea Papdiné Morovicz; Victoria Smith Arnesen; Diana C. Turcu; Sandra Ninzima; Katharina Spang; Camilla Krakstad; Julie Guillermet-Guibert; Aurélia E. Lewis ABSTRACT The class I phosphoinositide 3-kinase (PI3K) catalytic subunits p110α...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (16): jcs231639.
Published: 16 August 2019
... used for immune surveillance by dendritic cells, as a route of infection by viruses and protozoa, and as a nutrient uptake pathway in tumor cells. In this study, we explore the role of class I phosphoinositide 3-kinases (PI3Ks) during ligand-stimulated macropinocytosis. We find that macropinocytosis in...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (2): jcs224998.
Published: 24 January 2019
... abolished in cells lacking either PI3Ks or the downstream kinases PkbA and PkbR1. Macropinocytosis Akt SGK Phosphoinositide 3-kinase PI3K Endocytosis Dictyostelium Macropinocytosis is an ancient process used by cells to take up large amounts of fluid ( King and Kay, 2018 ; Swanson...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (2): 444–452.
Published: 15 January 2017
... formation of both pronuclear and zygote nuclear envelopes in the fertilised egg. Here, we determine that class-I phosphoinositide 3-kinases (PI3Ks) are needed for in vitro nuclear envelope formation. We show that, in vivo , PtdIns(3,4,5) P 3 is transiently located in vesicles around the male pronucleus at...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (7): 1369–1378.
Published: 01 April 2014
..., regulates the activity of metabolic and signaling enzymes, and controls the half-life of proteins by earmarking them for degradation. GSK-3 is unique in its mode of substrate recognition and the regulation of its kinase activity, which is repressed by pro-survival phosphoinositide 3-kinase (PI3K)–AKT...
Journal Articles
J Cell Sci (2013) 126 (14): 2979–2989.
Published: 15 July 2013
... promote the maturation of already-formed invadopodia. We present a model in which growth factor stimulation leads to phosphoinositide 3-kinase (PI3K) activity and formation of invadopodia, whereas adhesion signaling promotes exocytosis of proteinases at invadopodia. * Author for correspondence...
Journal Articles
J Cell Sci (2012) 125 (13): 3153–3163.
Published: 01 July 2012
... ). Additional mechanisms of activation exist and they can be necessary for full activation of PLCγ upon RTK stimulation or complementary ( Maffucci and Falasca, 2007 ). For instance phosphoinositide 3-kinase (PI3K) product phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5) P 3 ] induces strong activation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (11): 1819–1830.
Published: 01 June 2011
...Mohamed M. Bekhite; Andreas Finkensieper; Stephanie Binas; Jörg Müller; Reinhard Wetzker; Hans-Reiner Figulla; Heinrich Sauer; Maria Wartenberg VEGF-, phosphoinositide 3-kinase (PI3K)- and protein kinase C (PKC)-regulated signaling in cardiac and vascular differentiation was investigated in mouse...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (3): 313–323.
Published: 01 February 2009
...Michael C. Weiger; Chun-Chao Wang; Matej Krajcovic; Adam T. Melvin; John J. Rhoden; Jason M. Haugh During directed cell migration (chemotaxis), cytoskeletal dynamics are stimulated and spatially biased by phosphoinositide 3-kinase (PI3K) and other signal transduction pathways. Live-cell imaging...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (6): 796–803.
Published: 15 March 2008
...@kcl.ac.uk ) 17 12 2007 © The Company of Biologists Limited 2008 2008 PITP Axonal elongation Phosphoinositide 3-kinase Hippocampal neurons The establishment of neuronal morphology is essential for the functioning of the nervous system and is regulated through the integration of...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (24): 5160–5168.
Published: 15 December 2006
...Yvonne Lindsay; David McCoull; Lindsay Davidson; Nick R. Leslie; Alison Fairservice; Alex Gray; John Lucocq; C. Peter Downes Phosphatidylinositol (3,4,5) trisphosphate [PtdIns(3,4,5) P 3 ] is a lipid second messenger, produced by Type I phosphoinositide 3-kinases (PI 3-kinases), which mediates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (1): 31–46.
Published: 01 January 2006
... this differentiation process. Here, we report that engagement of α 6 and, to a lesser extent, α 3 integrin subunits after HT-29 cell adhesion on laminin 5 increases the expression of E-cadherin, which then organizes into nascent adherens junctions. We further identify that phosphoinositide 3-kinase (PI...
Journal Articles
J Cell Sci (2003) 116 (2): 247–257.
Published: 15 January 2003
...Nobukazu Araki; Tanenori Hatae; Aizo Furukawa; Joel A. Swanson Previous studies have shown that Fcγ receptor (FcR)-mediated phagocytosis and macropinocytosis in macrophages consist of two dissociable activities: a phosphoinositide 3-kinase (PI3K)-independent extension of phagocytic cups and a PI3K...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2002) 115 (20): 3947–3956.
Published: 15 October 2002
... and cell rounding. This response is dependent on PAK4 kinase activity but does not require Cdc42 interaction. Activated PAK4 localises to the cell periphery but not specifically in lamellipodia, and HGF induces localisation of wild-type PAK4 to the cell periphery. LY294002, a phosphoinositide 3-kinase...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2002) 115 (4): 699–711.
Published: 15 February 2002
...Justin Sturge; Jocelyne Hamelin; Gareth E. Jones Urokinase-type plasminogen activator (uPA)-uPA receptor (uPAR) and epidermal growth factor (EGF)-EGF receptor (EGFR) expression is highly correlated with breast cancer metastasis. Phosphoinositide 3-kinase (PI3K),small Rho GTPases, such as Cdc42 and...
Journal Articles
J Cell Sci (2001) 114 (16): 2903–2910.
Published: 15 August 2001
... stroke. There are, however, a number of pitfalls of methodologies currently employed to study PKB function, and therefore caution should be used in interpretation of such experiments. © The Company of Biologists Limited 2001 2001 Phosphoinositide 3-kinase PDK1 AGC kinases Docking sites...