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Keywords: Phosphoinositide
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Journal Articles
In collection:
Lipid Biology
J Cell Sci (2022) 135 (5): jcs259145.
Published: 3 February 2022
... of phosphoinositide kinases and the Dishevelled protein Dvl3 in the context of two receptor signaling cascades. Simultaneous overexpression of PI4KIIIα (also known as PI4KA) and PIP5KIγ (also known as PIP5K1C) had a synergistic effect on PtdIns P 2 synthesis that was recapitulated by overexpression of Dvl3...
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2021) 134 (7): jcs252411.
Published: 15 April 2021
... the macropinocytic cup ( Fig. 4 A) and therefore postulated a role for the GTPase in the hydrolysis of the phosphoinositide. Our subsequent experiments provided a plausible mechanism: we propose that through the adaptor APPL1, Rab5 recruits Inpp5b and OCRL to the membrane, two active phosphatases capable...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (3): jcs250670.
Published: 10 February 2021
... of autophagosome biogenesis. Autophagy Endosome Phosphoinositide Recycling Macroautophagy (hereafter referred to as autophagy) controls numerous fundamental physiological functions ( Levine and Klionsky, 2004 ; Mizushima, 2005 ; Ohsumi, 2001 ). During the autophagic process, sequestration...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (5): jcs229500.
Published: 28 February 2019
... and melanosome identity. PIKfyve FIG4 VAC14 PI(3,5)P2 Phosphoinositide Melanosome Lysosome PMEL Amyloid The protein complex composed of the kinase PIKfyve (also known as Fab1), the phosphatase FIG4 (also known as Sac3) and the scaffolding protein VAC14 (also known as ArPIKfyve) regulates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (16): jcs216408.
Published: 16 August 2018
...) is a phosphoinositide 5-phosphatase for phosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P3] and phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2]. Here we show, through depletion of SHIP2 in triple negative MDA-MB-231 cells and the use of SHIP2 inhibitors, that cell migration appears to be positively controlled...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2017) 130 (20): 3447–3454.
Published: 15 October 2017
...-phosphatase that dephosphorylates PI(4,5)P 2 , cause Lowe syndrome. Previously we showed that OCRL localizes to the primary cilium, which has a distinct membrane phospholipid composition, but disruption of phosphoinositides in the ciliary membrane is poorly understood. Here, we demonstrate that cilia from...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (6): 1101–1114.
Published: 15 March 2016
...William's Elong Edimo; Somadri Ghosh; Rita Derua; Veerle Janssens; Etienne Waelkens; Jean-Marie Vanderwinden; Pierre Robe; Christophe Erneux ABSTRACT Phosphoinositides, particularly phosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P3] and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (19): 3646–3659.
Published: 1 October 2015
... of a phosphoinositide-regulated stress sensor. 22 4 2015 18 8 2015 © 2015. Published by The Company of Biologists Ltd 2015 * Author for correspondence ( pierre.morsomme@uclouvain.be ) To examine sterol distribution using filipin, 10 ml of cells grown to a density of 0.5 OD 600 units/ml were...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (18): 3456–3465.
Published: 15 September 2015
... to growth factor stimulation and local production of the phosphoinositide lipid phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5) P 3 ] following phosphoinositide 3-kinase (PI3K) activation. The metabolism and turnover of phosphoinositides is complex – they act as signalling molecules as well...
Includes: Supplementary data
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2015) 128 (17): 3330–3344.
Published: 1 September 2015
.... and Balla , T. ( 2008 ). Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha . Mol. Biol. Cell   19 , 711 - 721 . 10.1091/mbc.E07-07-0713 Bankaitis , V. A. , Phillips , S. , Yanagisawa , L. , Li , X...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (11): 2130–2142.
Published: 1 June 2015
..., the adaptor protein complex 2 (AP2) has been secondarily lost, suggesting mechanistic divergence. Here, we characterise two phosphoinositide-binding monomeric clathrin adaptors, T. brucei (Tb)EpsinR and TbCALM, which in trypanosomes are represented by single genes, unlike the expansions present in animals...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (3): 553–565.
Published: 1 February 2015
... to be clarified. Here, we examined the phosphoinositide-lipid-binding capabilities of full-length SNX27, and discovered a new PtdIns P -binding site within the C-terminal 4.1, ezrin, radixin, moesin (FERM) domain. This binding site showed a clear preference for bi- and tri-phosphorylated phophoinositides...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (1): 118–128.
Published: 1 January 2015
... of cytosolic Ca 2+ response to high concentration of AngII in HEK293 cells that express wild type but not truncated AGTR1 (AT1a receptor), missing the phosphorylation sites. Efr3 depletion had minimal effect on the recovery of plasma membrane phosphoinositides during stimulation, and AT1 receptors still...
Journal Articles
J Cell Sci (2014) 127 (5): 923–928.
Published: 1 March 2014
...Steve Jean; Amy A. Kiger ABSTRACT The phosphoinositide 3-kinase (PI3K) family is important to nearly all aspects of cell and tissue biology and central to human cancer, diabetes and aging. PI3Ks are spatially regulated and multifunctional, and together, act at nearly all membranes in the cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (21): 4885–4899.
Published: 1 November 2013
.... , Cullen   P. J. ( 2004 ). Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides.   Curr. Biol.   14 , 1791 – 1800 . 10.1016/j.cub.2004.09.077 Choudhury   R. , Diao   A. , Zhang   F. , Eisenberg   E...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (7): 1683–1692.
Published: 1 April 2012
...-dependent rebinding to the yeast vacuole is required for homotypic vacuole fusion . J. Cell Biol.   157 , 79 - 89 . Bohdanowicz   M. , Cosio   G. , Backer   J. M. , Grinstein   S. ( 2010 ). Class I and class III phosphoinositide 3-kinases are required for actin polymerization...
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2011) 124 (15): 2602–2610.
Published: 1 August 2011
... Medical Research Foundation, Oklahoma City, OK 73104, USA ‡ Author for correspondence ( bab13@cornell.edu ) 13 4 2011 © 2011. 2011 Store-operated Ca 2+ entry Lipid raft Phosphoinositide STIM1 Orai1 Store-operated Ca 2+ entry (SOCE) is a ubiquitous process...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (8): 1245–1255.
Published: 15 April 2011
...; Mikko J. Frilander; Harri Savilahti; Hannu Sariola; Kirsi Sainio; Sanna Lehtonen; Jussi Taipale; Marjo Salminen; Pekka Lappalainen MIM/MTSS1 is a tissue-specific regulator of plasma membrane dynamics, whose altered expression levels have been linked to cancer metastasis. MIM deforms phosphoinositide...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (12): 2027–2036.
Published: 15 June 2008
... network is modulated by bacterial effectors, some of which, such as SigD/SopB, manipulate the level of endosomal phosphoinositides. Here, we establish that at early stages of Salmonella infection, sorting nexin-1 (SNX1) – a host phosphoinositide-binding protein that normally associates with early...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (10): 2084–2094.
Published: 15 May 2006
... is crucial for exocytosis to occur in mast cells, and may have a more general role in all professional secretory cells. 1 2 2006 © The Company of Biologists Limited 2006 2006 Phosphoinositides are a family of phospholipids containing myo -inositol as their headgroup. Despite a relatively...
Includes: Supplementary data