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Keywords: Phosphoinositide
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Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2023) 136 (16): jcs261494.
Published: 29 August 2023
... . Biochem. Bioph. Res. Commun. 319 , 456 - 463 . 10.1016/j.bbrc.2004.04.187 Berquez , M. , Gadsby , J. R. , Festa , B. P. , Butler , R. , Jackson , S. P. , Berno , V. , Luciani , A. , Devuyst , O. and Gallop , J. L. ( 2020 ). The phosphoinositide 3-kinase...
Includes: Supplementary data
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2022) 135 (5): jcs259145.
Published: 3 February 2022
... of phosphoinositide kinases and the Dishevelled protein Dvl3 in the context of two receptor signaling cascades. Simultaneous overexpression of PI4KIIIα (also known as PI4KA) and PIP5KIγ (also known as PIP5K1C) had a synergistic effect on PtdIns P 2 synthesis that was recapitulated by overexpression of Dvl3...
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2021) 134 (7): jcs252411.
Published: 15 April 2021
... the recruitment of 5-inositol phosphatases to circular ruffles. Macropinocytosis GTPase Rab Phosphatase Phosphoinositide EGF Ruffling Macropinocytosis is an actin-driven process that involves the formation and extension of plasma membrane ruffles and the eventual closure of large (≥0.2 to 5.0...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (3): jcs250670.
Published: 10 February 2021
... of autophagosome biogenesis. Autophagy Endosome Phosphoinositide Recycling Macroautophagy (hereafter referred to as autophagy) controls numerous fundamental physiological functions ( Levine and Klionsky, 2004 ; Mizushima, 2005 ; Ohsumi, 2001 ). During the autophagic process, sequestration...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (5): jcs229500.
Published: 28 February 2019
... by the PIKfyve complex regulates membrane remodeling of early melanosomes; this controls the import–export balance that is required for functional amyloid formation and melanosome identity. PIKfyve FIG4 VAC14 PI(3,5)P2 Phosphoinositide Melanosome Lysosome PMEL Amyloid The protein complex...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (16): jcs216408.
Published: 16 August 2018
...) is a phosphoinositide 5-phosphatase for phosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P3] and phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2]. Here we show, through depletion of SHIP2 in triple negative MDA-MB-231 cells and the use of SHIP2 inhibitors, that cell migration appears to be positively controlled...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2017) 130 (20): 3447–3454.
Published: 15 October 2017
...-phosphatase that dephosphorylates PI(4,5)P 2 , cause Lowe syndrome. Previously we showed that OCRL localizes to the primary cilium, which has a distinct membrane phospholipid composition, but disruption of phosphoinositides in the ciliary membrane is poorly understood. Here, we demonstrate that cilia from...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2015) 128 (19): 3646–3659.
Published: 1 October 2015
... of a phosphoinositide-regulated stress sensor. * Author for correspondence ( pierre.morsomme@uclouvain.be ) Competing interests The authors declare no competing or financial interests. 22 4 2015 18 8 2015 © 2015. Published by The Company of Biologists Ltd 2015 Summary: Yeast...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (18): 3456–3465.
Published: 15 September 2015
... to growth factor stimulation and local production of the phosphoinositide lipid phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5) P 3 ] following phosphoinositide 3-kinase (PI3K) activation. The metabolism and turnover of phosphoinositides is complex – they act as signalling molecules as well...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2015) 128 (11): 2130–2142.
Published: 1 June 2015
..., the adaptor protein complex 2 (AP2) has been secondarily lost, suggesting mechanistic divergence. Here, we characterise two phosphoinositide-binding monomeric clathrin adaptors, T. brucei (Tb)EpsinR and TbCALM, which in trypanosomes are represented by single genes, unlike the expansions present in animals...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2015) 128 (1): 118–128.
Published: 1 January 2015
... of cytosolic Ca 2+ response to high concentration of AngII in HEK293 cells that express wild type but not truncated AGTR1 (AT1a receptor), missing the phosphorylation sites. Efr3 depletion had minimal effect on the recovery of plasma membrane phosphoinositides during stimulation, and AT1 receptors still...
Journal Articles
J Cell Sci (2014) 127 (5): 923–928.
Published: 1 March 2014
...Steve Jean; Amy A. Kiger ABSTRACT The phosphoinositide 3-kinase (PI3K) family is important to nearly all aspects of cell and tissue biology and central to human cancer, diabetes and aging. PI3Ks are spatially regulated and multifunctional, and together, act at nearly all membranes in the cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (21): 4885–4899.
Published: 1 November 2013
...-positive early endosome. To elucidate the molecular mechanism for the phosphoinositide-independent association of SNX15 with clathrin-decorated elements of the early endocytic network we performed proteomics on SNX15 immuno-isolates. GFP-nanotrap pull-downs of cell extracts derived from HeLa cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (7): 1683–1692.
Published: 1 April 2012
.... * These authors contributed equally to this work ‡ Author for correspondence ( rfratti@illinois.edu ) 7 11 2011 © 2012. 2012 Fusion Phosphoinositide SNARE HOPS Phospholipase C Actin dynamics Membrane trafficking is utilized by all eukaryotes for the transportation of cargo...
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2011) 124 (15): 2602–2610.
Published: 1 August 2011
... address: Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA ‡ Author for correspondence ( bab13@cornell.edu ) 13 4 2011 © 2011. 2011 Store-operated Ca 2+ entry Lipid raft Phosphoinositide STIM1 Orai1 Store...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2008) 121 (12): 2027–2036.
Published: 15 June 2008
... network is modulated by bacterial effectors, some of which, such as SigD/SopB, manipulate the level of endosomal phosphoinositides. Here, we establish that at early stages of Salmonella infection, sorting nexin-1 (SNX1) – a host phosphoinositide-binding protein that normally associates with early...
Includes: Multimedia, Supplementary data