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Keywords: Phosphodiesterase
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Journal Articles
J Cell Sci (2006) 119 (5): 828–836.
Published: 1 March 2006
.... This probe was recently used in excitable cells to reveal an inverse relationship between cAMP and Ca 2+ oscillations as a consequence of Ca 2+ -dependent activation of phosphodiesterase 1 (PDE1). Here, we have used human embryonic kidney (HEK293) cells expressing the type 8 adenylyl cyclase (AC8) to examine...
Journal Articles
J Cell Sci (2004) 117 (11): 2377–2388.
Published: 1 May 2004
..., such as forskolin and IBMX. In particular, by using the specific inhibitor rolipram, we identify the PDE4 family of cAMP-specific phosphodiesterases as critical regulators of this process. The effect of PDE4 on microspike formation is mediated by actions exerted through the activation of PKA – rather than through...
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