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Keywords: Phosphatidylserine
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Journal Articles
J Cell Sci (2022) 135 (17): jcs259988.
Published: 30 August 2022
..., and that phosphatidylserine is involved in the activation of both signaling pathways. We also demonstrated that the Rho family GTPase Cdc42 contributes to the plasma membrane stress-induced activation of TORC2–Ypk1/2 signaling. Furthermore, we revealed that phosphatidylinositol-specific phospholipase C, Plc1, contributes...
Includes: Supplementary data
Journal Articles
In collection:
Lipid biology
J Cell Sci (2022) 135 (5): jcs256529.
Published: 17 May 2021
... in the plasma membrane of the living cells. We show here that a stable micron-scale protein-depleted region is generated in the plasma membrane of yeast mutants lacking phosphatidylserine at high temperatures. We named this region the ‘void zone’. Transmembrane proteins and certain peripheral membrane proteins...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2019) 132 (16): jcs231886.
Published: 22 August 2019
... of the mitochondrial ATP synthase. In this study, we show that overexpression of the mitochondrial targeting sequence of ATP5G1 perturbs glucose metabolism, inhibits oncogenic K-Ras signaling, and redistributes phosphatidylserine (PtdSer) to mitochondria and other endomembranes, resulting in K-Ras translocation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (5): jcs227660.
Published: 28 February 2019
...Yu-Zen Chen; Katharina Klöditz; Eui-Seung Lee; Diemmy Pham Nguyen; Quan Yuan; Jack Johnson; Yannick Lee-yow; Adam Hall; Shohei Mitani; Ning-Shao Xia; Bengt Fadeel; Ding Xue ABSTRACT The Caenorhabditis elegans aminophospholipid translocase TAT-1 maintains phosphatidylserine (PS) asymmetry...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (6): 1169–1178.
Published: 15 March 2017
... mechanism by which TORC2-Ypk1/Ypk2 regulates Rho1 is not well defined. Here, we found that Ypk1/Ypk2 maintain PM localization of Rho1 under PM stress via spatial reorganization of the lipids including phosphatidylserine. Genetic evidence suggests that this process is mediated by the Lem3-containing lipid...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (1): 65–79.
Published: 1 January 2016
...Tamara C. Hornik; Anna Vilalta; Guy C. Brown ABSTRACT Some apoptotic processes, such as phosphatidylserine exposure, are potentially reversible and do not necessarily lead to cell death. However, phosphatidylserine exposure can induce phagocytosis of a cell, resulting in cell death by phagocytosis...
Includes: Supplementary data
Journal Articles
In collection:
Lipid biology
J Cell Sci (2015) 128 (11): 2021–2032.
Published: 1 June 2015
.... , Muthusamy , B. P. , Liu , K. , Zare , S. , Andersen , R. J. and Graham , T. R. ( 2006 ). Roles for the Drs2p-Cdc50p complex in protein transport and phosphatidylserine asymmetry of the yeast plasma membrane . Traffic   7 , 1503 - 1517 . 10.1111/j.1600-0854.2006.00485.x Chen...
Journal Articles
J Cell Sci (2015) 128 (7): 1422–1433.
Published: 1 April 2015
... version of the biosensor, we show that plasmalemmal phosphatidylserine is essential for retaining cholesterol in the cytosolic leaflet of the plasma membrane. In vitro experiments reveal that 1-stearoy-2-oleoyl phosphatidylserine can induce phase separation in cholesterol-containing lipid bilayers...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (24): 6157–6165.
Published: 15 December 2012
...Yidi Sun; David G. Drubin Summary Anionic phospholipids PI(4,5)P 2 and phosphatidylserine (PS) are enriched in the cytosolic leaflet of the plasma membrane where endocytic sites form. In this study, we investigated the roles of PI(4,5)P 2 and PS in clathrin-mediated endocytosis (CME) site...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (6): 1233–1243.
Published: 15 March 2005
... channels with subsequent Ca 2+ entry and stimulates a sphingomyelinase with subsequent formation of ceramide. Ca 2+ and ceramide then activate a scramblase leading to breakdown of phosphatidylserine asymmetry of the cell membrane. The mediators accounting for activation of erythrocyte sphingomyelinase...
Journal Articles
In collection:
Lipid biology
J Cell Sci (1999) 112 (1): 11–20.
Published: 1 January 1999
..., ejaculated and cryopreserved ram spermatozoa was studied by labeling cells with fluorescent analogues of phosphatidylserine and phosphatidylcholine. By co-labeling cells with the DNA-binding dye propidiumiodide as well as by employing fluorescence microscopy and flow cytometry we were able to determine...