... in the morphogenesis of the T-tubule system, suggesting a new model for the molecular pathology of dysferlin-dependent muscular dystrophy. Dysferlin T-tubule system Muscular dystrophy Dysferlinopathy Phosphatidylinositol 4 5-bisphosphate C2 domain protein Limb-girdle muscular dystrophy type 2B Miyoshi...

...-bisphosphate indicating that these lipids regulate β 1 and β 2 integrin-mediated adhesion. In vivo, these lipids can be generated by phospholipase D2 and phosphatidylinositol 4-phosphate 5-kinase Iγ b , respectively, and over-expression of catalytically-functional forms of these enzymes dose-dependently...