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Keywords: Phosphatidic acid
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Journal Articles
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Mechanobiology
J Cell Sci (2019) 132 (17): jcs232579.
Published: 02 September 2019
... on membrane trafficking. Here, we reveal that an acute decrease of PM tension results in phosphatidic acid (PA) production, F-actin and phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P 2 ]-enriched dorsal membrane ruffling and subsequent macropinocytosis in myoblasts. The PA production induced by decreased...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (3): 516–526.
Published: 01 February 2015
... activation. In addition, AURA phosphorylates PLD, so both proteins engage in a positive reinforcement loop. AURA and PLD2 form a protein–protein complex and colocalize to cytoplasmic regions in cells. The reason why PLD activates AURA is because of the production of phosphatidic acid by the lipase, which...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (18): 3799–3810.
Published: 15 September 2006
... to the trans -Golgi stack and conferring Ca 2+ -stimulated intracellular redistribution in a manner that is dependent on the phospholipase-D-mediated generation of phosphatidic acid. The LxDFF motif within helix-1 is pivotal to this, where Leu4-Phe6-Phe7 forms a compact hydrophobic pocket on one side of helix...
Journal Articles
J Cell Sci (2004) 117 (19): 4365–4375.
Published: 01 September 2004
... intracellular localization. To determine the phospholipids to which they bind, a protein phospholipid overlay assay was performed. Our results indicate that the class-I Rab11-FIPs bind preferentially to phosphatidylinositol-(3,4,5)-trisphosphate [PtdIns(3,4,5) P 3 ] and the second messenger phosphatidic acid...