..., which is known to regulate phagosome fusion in the wild-type cells, reduced the rate of phagosome fusion in RabD Q67L+ cells, indicating that RabD acted upstream of or parallel with PI 3-kinase. We hypothesize that RabD and, possibly, Rab14, a related GTPase that associates with phagosomes in mammalian...

... in pH might trigger homotypic phagosome fusion. A pkbA null cell line (PKB/Akt) reproduced the phenotype described for cells treated with PI 3-kinase inhibitors and Δ ddpik1/ddpik2 cells. We propose that PI 3-kinases, through a PKB/Akt dependent pathway, directly regulate homotypic fusion of single...

... * Present address: MPI fur Infektionsbiologie, Monbijoustrasse 2, D-11017 Berlin, Germany 11 07 1996 23 10 1996 © 1997 by Company of Biologists 1997 Leishmania mexicana Phagosome fusion Annexin Fig. 1. Bone marrow derived macrophages were infected for 2 days...