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Keywords: Phagosome
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Membrane trafficking
J Cell Sci (2023) 136 (9): jcs260806.
Published: 12 May 2023
...Julia Becker; Ariane Schleinitz; Christina Hermsen; Sabrina Rappold; Paul Saftig; Andreas Jeschke; Albert Haas ABSTRACT Several ATP- and cytosol-dependent fusion processes between membranes of the endocytic and exocytic pathways have been biochemically reconstituted. Here, we present a phagosome...
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Imaging
J Cell Sci (2021) 134 (5): jcs252320.
Published: 11 February 2021
.... We report that interaction between macrophages and the elongated and highly motile borreliae can lead to formation of membrane tunnels that extend deeper into the host cytoplasm than the actual phagosome, most probably as a result of partial extrication of captured borreliae. We also show...
Includes: Supplementary data
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J Cell Sci (2017) 130 (4): 735–744.
Published: 15 February 2017
...Anke Di; Tomohiro Kiya; Haixia Gong; Xiaopei Gao; Asrar B. Malik ABSTRACT Acidification of macrophage phagosomes serves an important bactericidal function. We show here that the redox-sensitive transient receptor potential (TRP) cation channel TRPM2 is expressed in the phagosomal membrane...
Includes: Supplementary data
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J Cell Sci (2014) 127 (17): 3852–3861.
Published: 1 September 2014
...) phagocytosis by the RPE provides a unique opportunity to analyse phagosome processing in vivo . In mouse retinae, phagosomes containing stacked rhodopsin-rich discs were identified by immuno-electron microscopy. Early apical phagosomes stained with antibodies against both cytoplasmic and intradiscal domains...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (9): 2071–2082.
Published: 1 May 2014
...Gang Pei; Urska Repnik; Gareth Griffiths; Maximiliano Gabriel Gutierrez ABSTRACT Interferon-γ (IFN-γ) has been shown to regulate phagosome trafficking and function in macrophages, but the molecular mechanisms involved are poorly understood. Here, we identify Rab20 as part of the machinery by which...
Includes: Supplementary data
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Journal Articles
J Cell Sci (2012) 125 (11): 2698–2708.
Published: 1 June 2012
... limiting bacterial replication in both, professional phagocytes and in non-phagocytic cells in vitro, and helps mice to successfully battle Salmonella infection in vivo. With respect to the interaction with the lysosomal system, the SCV apparently deviates from the default phagosome maturation pathway...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (14): 2502–2511.
Published: 15 July 2010
... factors at the plasma membrane, but it has also been implicated in binding and transport of some lysosomal proteins. However, the role of sortilin during phagosome maturation has not been investigated before. Here, we show that in macrophages, sortilin is mainly localized in the Golgi and transported...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (21): 3838–3849.
Published: 1 November 2007
... endocytic motif within the C-terminus. P2X 4 receptors remained stable within the proteolytic environment of the lysosome and resisted degradation by virtue of their N-linked glycans. Stimulation of phagocytosis triggered the accumulation of P2X 4 receptors at the phagosome membrane. Stimulating lysosome...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (13): 2813–2825.
Published: 1 July 2005
... 2005 V-ATPase RNAi Contractile vacuole Phagosome Trichocyst The vacuolar-proton-ATPase (V-ATPase) translocates protons across membranes against their electrochemical potential through ATP hydrolysis. The V-ATPase is responsible for the acidification of organelles like phagosomes...
Journal Articles
J Cell Sci (2003) 116 (8): 1579–1587.
Published: 15 April 2003
... cells, 75% of internalized conidia were found in phagosomes containing LAMP-1 120 minutes post-infection. In A549 cells, 55% and 58% of internalized conidia were found to co-localize with LAMP-1 and CD63 by 24 hours. Cathepsin D also co-localized with internalized conidia in A549 cells. Phagosomes...
Journal Articles
J Cell Sci (2002) 115 (14): 2893–2905.
Published: 15 July 2002
... visualization of the trafficking of vacuolar proton pumps in this pathway, which appeared to be entirely independent from the contractile vacuole membrane system. In cells whose endosomes were pre-labeled with TRITC-dextran and then fed yeast particles,VatM-GFP was delivered to newly formed yeast phagosomes...
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Journal Articles
Journal Articles
J Cell Sci (1999) 112 (3): 307–316.
Published: 1 February 1999
...Joel A. Swanson; Melissa T. Johnson; Karen Beningo; Penny Post; Mark Mooseker; Nobukazu Araki ABSTRACT Studies of Fc-mediated phagocytosis by mouse macrophages identified a contractile activity at the distal margins of forming phagosomes. Time-lapse video microscopic analysis of macrophages...
Journal Articles
J Cell Sci (1998) 111 (19): 2855–2866.
Published: 10 January 1998
.... In both control and activated macrophages, expression of the protein is 3-to 4-fold higher in wild-type compared to mutant macrophages. In Leishmania major -infected macrophages, Nramp1 is observed in the membrane of the pathogen-containing phagosomes, which retain a perinuclear localization in resting...
Journal Articles
J Cell Sci (1998) 111 (1): 141–148.
Published: 1 January 1998
...Torunn Elisabeth Tjelle; Babita Saigal; Marianne Frøystad; Trond Berg ABSTRACT Phagosomes are formed when phagocytic cells ingest particles such as bacteria, viruses or synthetic beads of different kinds. The environment within the phagosome gradually changes to generate degradative conditions...
Journal Articles
J Cell Sci (1997) 110 (10): 1199–1213.
Published: 15 May 1997
... internalized latex beads, both with and without IgG opsonization. Our results show that whereas all these annexins are present on both the plasma membrane and on phagosomes, the localization on other organelles differs. Annexins I, II, III and V were detected on early endosomes, while only annexin V was seen...
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