... Autophagosome Phagophore ATG16L1 Atg16 Lipid binding Membrane recruitment Single-membrane lipidation Cancer Research UK 10.13039/501100000289 C52370/A21586 Autophagosomes are distinct double-membrane vesicles that form de novo to encapsulate and deliver cellular components...

...-associated phagocytosis Lysosome Phagophore Norges Forskningsråd 10.13039/501100005416 249884 Kreftforeningen 10.13039/100008730 190214 Helse Nord RHF 10.13039/501100007137 HNF1449-19 Autophagy is an evolutionary conserved intracellular renovation process...

.... , Brumell   J. H. , Ferro-Novick   S. , Klionsky   D. J. ( 2010 ). Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy.   Proc. Natl. Acad. Sci. USA   107 , 7811 – 7816 . 10.1073/pnas.1000063107 Lystad   A. H. , Ichimura   Y. , Takagi   K. , Yang   Y...

... the formation of the phagophore from omegasome or cradle-like ER structures and ATG9-positive membranes, by an as-yet-unknown mechanism. WIPI proteins, as shown for WIPI1, WIPI2 and WIPI4, localize to the phagophore. Here, WIPI2 recruits the ATG12–ATG5–ATG16L complex (highlighted in green) by direct binding...

... no competing interests. © 2015. Published by The Company of Biologists Ltd 2015 Phagophore assembly site Pre-autophagosomal membrane Phagophore Isolation membrane Autophagosome Autophagy Endoplasmic reticulum exit site Autophagy is a highly conserved catabolic process that is activated...

... 2013. Published by The Company of Biologists Ltd 2013 Microtubule Macroautophagy Phagocytosis Phagophore Cell signaling Lysosome Acetylation Molecular motor Autophagy is a catabolic process that leads to the degradation of cytoplasmic components by lysosomes. There are several...