...Mohammed A. Abdelsaid; Azza B. El-Remessy Summary Although promising, the ability to regulate angiogenesis through delivery of VEGF remains an unrealized goal. We have shown previously that physiological levels of peroxynitrite (1 µM) are required for a VEGF-mediated angiogenic response, yet...

...Andrea Guidarelli; Liana Cerioni; Orazio Cantoni In intact U937 cells, peroxynitrite promotes the mitochondrial formation of superoxide via a Ca 2+ -dependent mechanism involving inhibition of complex III. Superoxide then readily dismutates to H 2 O 2 causing lesions on different biomolecules...

... its precise role in pathological progression remains unclear. We examine here the potentially interrelated roles of tPA, NO and peroxynitrite (ONOO – ), which is the toxic metabolite of NO, in BBB breakdown and neurodegeneration following intrahippocampal injection of the glutamate analog kainite (KA...

...-survival function via peroxynitrite-mediated alteration of the Akt-1/p38 MAP kinase signaling pathway by studies of retinal endothelial cells in vitro. High glucose or exogenous peroxynitrite caused significant increases in apoptosis in the presence or absence of VEGF. Treatment with a peroxynitrite...