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Keywords: Peroxisome
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Journal Articles
J Cell Sci jcs.259091.
Published: 21 October 2021
...Nicolò Ilacqua; Irene Anastasia; Andrea Raimondi; Philippe Lemieux; Thomas Q. de Aguiar Vallim; Katalin Toth; Eugene V. Koonin; Luca Pellegrini Hepatic lipid homeostasis depends on intracellular pathways that respire fatty acid (FA) in peroxisomes and mitochondria and on systemic pathways...
Journal Articles
In collection:
Autophagy
J Cell Sci (2021) 134 (9): jcs254714.
Published: 11 May 2021
.... In the methylotrophic yeast Komagataella phaffii (Kp; also known as Pichia pastoris ), the plasma membrane protein KpWsc1 senses environmental methanol concentrations and transmits this information to induce the expression of genes for methanol metabolism and the formation of huge peroxisomes. In this study, we show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (16): jcs246983.
Published: 17 August 2020
... family proteins localize to the endoplasmic reticulum (ER). Pex24 and Pex32, but not Pex23 and Pex29, predominantly accumulate at peroxisome–ER contacts. Upon deletion of PEX24 or PEX32 – and to a much lesser extent, of PEX23 or PEX29 – peroxisome–ER contacts are lost, concomitant with defects...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (9): jcs236943.
Published: 11 May 2020
...Yukio Fujiki; Yuichi Abe; Yuuta Imoto; Akemi J. Tanaka; Kanji Okumoto; Masanori Honsho; Shigehiko Tamura; Non Miyata; Toshihide Yamashita; Wendy K. Chung; Tsuneyoshi Kuroiwa ABSTRACT Peroxisomes are single-membrane organelles present in eukaryotes. The functional importance of peroxisomes in humans...
Journal Articles
In collection:
Mitochondria
J Cell Sci (2019) 132 (11): jcs224766.
Published: 31 May 2019
...Hideaki Tanaka; Tomohiko Okazaki; Saeko Aoyama; Mutsumi Yokota; Masato Koike; Yasushi Okada; Yukio Fujiki; Yukiko Gotoh ABSTRACT Peroxisomes cooperate with mitochondria in the performance of cellular metabolic functions, such as fatty acid oxidation and the maintenance of redox homeostasis. However...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (6): jcs223016.
Published: 18 March 2019
... peroxisomal membrane protein that generates the fatty alcohols required for the biosynthesis of ether lipids. Lipid droplet localization of exogenously expressed and endogenous human Far1 was observed by fluorescence microscopy under conditions of increased triglyceride synthesis in tissue culture cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (14): jcs212977.
Published: 27 July 2018
... that myogenic fetal cells have distinct metabolic requirements compared to those proliferating during regeneration, with the former displaying a low respiration demand relying mostly on glycolysis. Furthermore, we show distinct requirements for peroxisomal and mitochondrial fatty acid oxidation (FAO...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs207522.
Published: 07 February 2018
...Sanjeev Kumar; Rinse de Boer; Ida J. van der Klei ABSTRACT Here, we used fluorescence microscopy and a peroxisome-targeted tandem fluorescent protein timer to determine the relative age of peroxisomes in yeast. Our data indicate that yeast cells contain a heterogeneous population of relatively old...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (2): jcs202978.
Published: 29 January 2018
...Francisco J. Corpas; Juan B. Barroso; Jenny Russinova ABSTRACT Plant peroxisomes are recognized organelles that – with their capacity to generate greater amounts of H 2 O 2 than other subcellular compartments – have a remarkable oxidative metabolism. However, over the last 15 years, new information...
Journal Articles
J Cell Sci (2018) 131 (2): jcs201467.
Published: 29 January 2018
...Francisco J. Corpas; Juan B. Barroso; Jenny Russinova ABSTRACT Ca 2+ is a second messenger in many physiological and phytopathological processes. Peroxisomes are subcellular compartments with an active oxidative and nitrosative metabolism. Previous studies have demonstrated that peroxisomal nitric...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (5): 853–867.
Published: 01 March 2017
... the division of mitochondrion, plastid and peroxisome. Here, using isolated peroxisome-dividing (POD) machinery from a unicellular red algae, Cyanidioschyzon merolae , we identified a dynamin-based ring organizing center (DOC) that acts as an initiation point for formation of the dynamin-based ring. C. merolae...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (21): 4067–4075.
Published: 01 November 2016
...Eden Yifrach; Silvia G. Chuartzman; Noa Dahan; Shiran Maskit; Lior Zada; Uri Weill; Ido Yofe; Tsviya Olender; Maya Schuldiner; Einat Zalckvar ABSTRACT To optimally perform the diversity of metabolic functions that occur within peroxisomes, cells must dynamically regulate peroxisome size, number...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (21): 4057–4066.
Published: 01 November 2016
...Daniel Effelsberg; Luis Daniel Cruz-Zaragoza; Wolfgang Schliebs; Ralf Erdmann ABSTRACT Peroxisomal proteins carrying a type 1 peroxisomal targeting signal (PTS1) are recognized by the well-conserved cycling import receptor Pex5p. The yeast YMR018W gene encodes a Pex5p paralog and newly identified...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (7): 1327–1340.
Published: 01 April 2015
...Jinlan Chang; Mary J. Klute; Robert J. Tower; Fred D. Mast; Joel B. Dacks; Richard A. Rachubinski ABSTRACT The peroxin Pex11 has a recognized role in peroxisome division. Pex11p remodels and elongates peroxisomal membranes prior to the recruitment of dynamin-related GTPases that act in membrane...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (20): 4698–4706.
Published: 15 October 2013
...Jinlan Chang; Robert J. Tower; David L. Lancaster; Richard A. Rachubinski Summary Dynein is a large macromolecular motor complex that moves cargo along microtubules. A motor-independent role for the light chain of dynein, Dyn2p, in peroxisome biology in Saccharomyces cerevisiae was suggested from...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (10): 1759–1768.
Published: 15 May 2011
...Pratima Bharti; Wolfgang Schliebs; Tanja Schievelbusch; Alexander Neuhaus; Christine David; Klaus Kock; Christian Herrmann; Helmut E. Meyer; Sebastian Wiese; Bettina Warscheid; Carsten Theiss; Ralf Erdmann We have established a procedure for isolating native peroxisomal membrane protein complexes...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (14): 2331–2336.
Published: 15 July 2009
...Ewald H. Hettema; Alison M. Motley With every cell division, peroxisomes duplicate and are segregated between progeny cells. Here, we discuss the different modes of peroxisome multiplication and the machinery that is involved in each case. Peroxisomes have been considered by many to be peripheral...
Journal Articles
J Cell Sci (2008) 121 (10): 1633–1640.
Published: 15 May 2008
...Alison M. Motley; Gemma P. Ward; Ewald H. Hettema Yeast peroxisomes multiply by fission. Fission requires two dynamin-related proteins, Dnm1p and Vps1p. Using an in vivo fission assay, we show that Dnm1p-dependent peroxisome fission requires Fis1p, Caf4p and Mdv1p. Fluorescence microscopy of cells...
Journal Articles
J Cell Sci (2006) 119 (19): 3994–4001.
Published: 01 October 2006
... that Vps1p, but not Dnm1p, plays a role in regulating peroxisome abundance. Here we show that deletion of DNM1 also results in reduction of peroxisome numbers. This was not observed in glucose-grown dnm1 cells, but was evident in cells grown in the presence of oleate. Similar observations were made in cells...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (9): 1961–1972.
Published: 01 May 2006
...Matthew J. Lingard; Richard N. Trelease Pex11 homologs and dynamin-related proteins uniquely regulate peroxisome division (cell-cycle-dependent duplication) and proliferation (cell-cycle-independent multiplication). Arabidopsis plants possess five Pex11 homologs designated in this study...
Includes: Supplementary data