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Keywords: Pax7
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Journal Articles
J Cell Sci (2017) 130 (21): 3685–3697.
Published: 01 November 2017
... has bimodal effects, inhibiting myogenic differentiation and blocking MyoD at low levels of expression, and killing myoblasts at high levels. Pax3 and Pax7, which contain related homeodomains, antagonize the cell death phenotype of DUX4 in C2C12 cells, suggesting some type of competitive interaction...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (8): 1699–1711.
Published: 15 April 2014
...Francesca Riuzzi; Guglielmo Sorci; Roberta Sagheddu; Angelo Sidoni; Rita Alaggio; Vito Ninfo; Rosario Donato ABSTRACT Embryonal rhabdomyosarcomas (ERMSs) show elevated levels of PAX7, a transcription factor that marks quiescent adult muscle stem (satellite) cells and is important for proliferation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (8): 1868–1880.
Published: 15 April 2013
... cell pool. The most lateral fraction of the fast domain in the myotome of zebrafish embryos derives from the Pax7-positive dermomyotome-like cells. In this study, we show that two genes, belonging to the sine oculus class 1 ( six1 ) genes ( six1a and six1b ), are both essential for the regulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (7): 1738–1749.
Published: 01 April 2012
... capacity is not altered. By contrast, Pax7 haploinsufficiency does not show major modifications by transcriptome analysis. These observations provide a mechanism linking Myf5 levels to muscle stem cell heterogeneity and fate by exposing two distinct and opposing phenotypes associated with Myf5...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (6): 1440–1454.
Published: 15 March 2012
...Francesca Riuzzi; Guglielmo Sorci; Roberta Sagheddu; Rosario Donato Expression of the paired-box 7 (PAX7) transcription factor is regulated during both myoblast proliferation and differentiation: high levels of PAX7 compromise myogenic differentiation because of excess and prolonged proliferation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (15): 2632–2639.
Published: 01 August 2010
... to the hypaxial and limb musculature ( Buckingham et al., 2002 ). Pax7 is expressed later, in the central dermomyotome ( Jostes et al., 1990 ), and is thought to be essential only during postnatal myogenesis ( Seale et al., 2000 ). A cell population has been identified that expresses both Pax3 and Pax7...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (24): 4427–4438.
Published: 15 December 2009
... degradative pathway. J. Cell Biol. 166 , 1041 -1054. Halevy, O., Piestun, Y., Allouh, M. Z., Rosser, B. W., Rinkevich, Y., Reshef, R., Rozenboim, I., Wleklinski-Lee, M. and Yablonka-Reuveni, Z. ( 2004 ). Pattern of Pax7 expression during myogenesis in the posthatch chicken establishes a model...
Journal Articles
J Cell Sci (2008) 121 (22): 3815–3823.
Published: 15 November 2008
... in vitro or C2C12 myogenic cells, we found that Notch activity is essential for maintaining the expression of Pax7, a transcription factor associated with the self-renewal lineage, in quiescent undifferentiated myoblasts after they exit the cell cycle. Stimulation of the Notch pathway by expression...
Journal Articles
J Cell Sci (2008) 121 (9): 1373–1382.
Published: 01 May 2008
... Pax7 without any MyoD – therefore, adopting the self-renewal pathway, with fewer cells undergoing myogenic differentiation. Similarly, preventing the degradation of endogenous β-catenin by inhibiting GSK3β activity also results in more Pax7-positive–MyoD-negative (Pax7 + MyoD – ) satellite-cell progeny...
Journal Articles
J Cell Sci (2007) 120 (23): 4178–4187.
Published: 01 December 2007
... expression of Lbx1 in satellite-cell-derived C2C12 myoblast cells resulted in severe depression of myogenic differentiation and incomplete myotube formation, concomitantly with the activation of the paired-box transcription factor Pax7 and depression of the myogenic regulatory factor MyoD. Moreover...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (9): 1824–1832.
Published: 01 May 2006
... satellite cells express the transcription factor Pax7 and when activated, coexpress Pax7 with MyoD. Most then proliferate, downregulate Pax7 and differentiate. By contrast, others maintain Pax7 but lose MyoD and return to a state resembling quiescence. Here we show that Pax7 is able to drive transcription...