... is required for maximal Leishmania uptake by macrophages and disease in a mouse model of cutaneous leishmaniasis. Leishmania Kinase Pathogen Parasite Macrophage National Institutes of Health http://dx.doi.org/10.13039/100000002 K08 AI103036 R01 AI146349-S1 R01 AI146349...

... of phagolysosomes where phagocytosed material is digested. Through this killing function, phagosome maturation is a central reaction of innate immune defence. Some intracellular pathogens, such as Mycobacterium tuberculosis and Chlamydia trachomatis , have evolved mechanisms to circumvent normal phagosome...

...Lee Dolat; Raphael H. Valdivia ABSTRACT Our understanding of how the obligate intracellular bacterial pathogen Chlamydia trachomatis reprograms the function of infected cells in the upper genital tract is largely based on observations made in cell culture with transformed epithelial cell lines...

... historically focused on the antiviral effects of ISGylation, which blocks the entry, replication or release of different intracellular pathogens. However, recently, new functions of ISGylation have emerged that implicate it in multiple cellular processes, such as DNA repair, autophagy, protein translation...

...Ron Mittler; Lee Simon; Eric Lam ABSTRACT Sacrificing an infected cell or cells in order to prevent systemic spread of a pathogen appears to be a conserved strategy in both plants and animals. We studied some of the morphological and biochemical events that accompany programmed cell death during...