... from Disp-deficient cells is restored by pharmacological membrane cholesterol extraction and by overexpression of transgenic Disp or the structurally related protein Patched 1 (Ptc, also known as Ptch1; a putative cholesterol transporter). These data suggest that Disp can regulate Shh function via...

...Sabrina L. Walthall; Michelle Moses; Jamila I. Horabin Hedgehog acts as an organizer during development. Its signaling involves the receptor Patched, signal transducer Smoothened and a cytoplasmic complex containing the transcription factor Cubitus interruptus tethered to the Smoothened carboxyl...

... developing Drosophila wing. Development 122 , 2261 -2269. Capdevila, J., Pariente, F., Sampedro, J., Alonso, J. L. and Guerrero, I. ( 1994 ). Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos...

... truncated variants inactive at eliciting a hedgehog-dependent response, but they competed with the wild-type protein for function and therefore served as functional antagonists. These variants were indistinguishable from wild-type sonic hedgehog in their ability to bind the receptor patched-1, but failed...