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Keywords: Pancreatic cancer
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Journal Articles
Paalini Sathiyaseelan, Suganthi Chittaranjan, Steve E. Kalloger, Jennifer Chan, Nancy E. Go, Mario A. Jardon, Cally J. Ho, Theodore Hui, Jing Xu, Christine Chow, Dongxia Gao, Fraser D. Johnson, William W. Lockwood, Gregg B. Morin, Daniel J. Renouf, David F. Schaeffer, Sharon M. Gorski
Journal:
Journal of Cell Science
J Cell Sci (2023) 136 (19): jcs260644.
Published: 11 October 2023
... adenocarcinoma is associated with poor clinical outcomes, and combined loss of ATG4B and ATG4A results in cell cycle defects, with implications for therapeutic strategies. Autophagy ATG4B ATG4A Pancreatic cancer PDAC CEP131 Centrosome PCM1 pro-LC3B GABARAP Doryphagy Pancreas Centre BC...
Includes: Supplementary data
Journal Articles
Vasileios Papalazarou, James Drew, Amelie Juin, Heather J. Spence, Jamie Whitelaw, Colin Nixon, Manuel Salmeron-Sanchez, Laura M. Machesky
Journal:
Journal of Cell Science
J Cell Sci (2022) 135 (24): jcs259978.
Published: 22 December 2022
...Vasileios Papalazarou; James Drew; Amelie Juin; Heather J. Spence; Jamie Whitelaw; Colin Nixon; Manuel Salmeron-Sanchez; Laura M. Machesky ABSTRACT Pancreatic cancer is a deadly and highly metastatic disease, although how metastatic lesions establish is not fully understood. A key feature...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2017) 130 (6): 1078–1093.
Published: 15 March 2017
...Jing Wang; Kumar Nikhil; Keith Viccaro; Lei Chang; Max Jacobsen; George Sandusky; Kavita Shah ABSTRACT We uncovered a crucial role for the Aurora kinase A (AURKA)–Twist1 axis in promoting epithelial-to-mesenchymal transition (EMT) and chemoresistance in pancreatic cancer. Twist1 is the first EMT...
Includes: Supplementary data
Journal Articles
Zhi-Hui Deng, Timothy S. Gomez, Douglas G. Osborne, Christine A. Phillips-Krawczak, Jin-San Zhang, Daniel D. Billadeau
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (2): 373–384.
Published: 15 January 2015
... indicate that FAM21 depletion sensitizes pancreatic cancer cells to gemcitabine and 5-fluorouracil. Thus, FAM21 not only functions as an integral component of the cytoplasmic WASH complex, but also modulates NF-κB gene transcription in the nucleus. To investigate whether FAM21 or WASH regulates NF-κB...
Includes: Supplementary data
Journal Articles
Helene Damhofer, Veronique L. Veenstra, Johanna A. M. G. Tol, Hanneke W. M. van Laarhoven, Jan Paul Medema, Maarten F. Bijlsma
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (1): 129–139.
Published: 1 January 2015
... pancreatic cancer cells, but that this solubilization decreases the potency of cancer cells to signal to adjacent stromal cells in direct co-culture models. These findings imply that under certain conditions, cancer-cell-tethered Hh molecules are the more potent signaling activators and that retaining Hh...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2013) 126 (15): 3380–3389.
Published: 1 August 2013
...Johannes Fredebohm; Jonas Wolf; Jörg D. Hoheisel; Michael Boettcher Summary Chemotherapy of advanced pancreatic cancer has mainly been gemcitabine-based for the past 15 years, with only limited effect. Recently, combination therapy that also targets checkpoint kinase 1 (CHK1) has become...
Includes: Supplementary data
Journal Articles
Martina Brandl, Barbara Seidler, Ferdinand Haller, Jerzy Adamski, Roland M. Schmid, Dieter Saur, Günter Schneider
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (24): 4231–4239.
Published: 15 December 2010
... in particular cancers. * Author for correspondence ( [email protected] ) 17 8 2010 © 2010. 2010 EMT IKK NFκB Pancreatic cancer SMAD SNAIL SLUG TGFβ Transforming growth factor β (TGFβ) controls various cellular processes, including cell proliferation...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (10): 1684–1692.
Published: 15 May 2010
... that BMP-9 promotes the proliferation of these cells via ALK-1. Furthermore, in vivo angiogenesis was promoted by BMP-9 in a Matrigel plug assay and in a BxPC3 xenograft model of human pancreatic cancer. Consistent with these in vivo findings, BMP-9 enhanced the proliferation of in-vitro-cultured normal...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2005) 118 (20): 4901–4912.
Published: 15 October 2005
.... and Malfertheiner, P. ( 2002 ). Reduced PTEN expression in the pancreas overexpressing transforming growth factor-beta 1. Br. J. Cancer 86 , 257 -262. Ellenrieder, V., Hendler, S., Ruhland, S., Boeck, W., Adler, G. and Gress, T. M. ( 2001a ). TGF-β-induced invasiveness of pancreatic cancer cells...
Journal Articles
Hendrik Ungefroren, Marie-Luise Kruse, Anna Trauzold, Stefanie Roeschmann, Christian Roeder, Alexander Arlt, Doris Henne-Bruns, Holger Kalthoff
Journal:
Journal of Cell Science
J Cell Sci (2001) 114 (15): 2735–2746.
Published: 1 August 2001
...Hendrik Ungefroren; Marie-Luise Kruse; Anna Trauzold; Stefanie Roeschmann; Christian Roeder; Alexander Arlt; Doris Henne-Bruns; Holger Kalthoff In this study we investigated the functional role of FAP-1 as a potential inhibitor of CD95 (Fas, APO-1)-mediated apoptosis in pancreatic cancer cells...