... the viability of the organism in the face of altered proteostasis ( Han and Kaufman, 2017 ; Hetz and Papa, 2018 ; Walter and Ron, 2011 ). Unfolded protein response Endoplasmic reticulum IRE1 XBP1 PERK eIF2α ATF4 ATF6 Pancreas Eye Summary: We review evidence that normally developing...

... rat pancreas: transdifferentiation of exocrine to hepatocyte-like cells in primary culture . Hepatology 39 , 1499 - 1507 . Liu P. , Cheng H. , Roberts T. M. , Zhao J. J. ( 2009 ) Targeting the phosphoinositide 3-kinase pathway in cancer . Nat. Rev. Drug Discov. 8...

...Karen Wallace; Carylyn J. Marek; Stefan Hoppler; Matthew C. Wright Developmentally, the pancreas and liver are closely related and pathological conditions – including elevated glucocorticoid levels – result in the appearance of hepatocytes in the pancreas. The role of the WNT signalling pathway...

...James R. Dutton; Naomi L. Chillingworth; Daniel Eberhard; Claire R. Brannon; Mark A. Hornsey; David Tosh; Jonathan M. W. Slack Insulin-secreting β cells were thought to reside only in the pancreas. Here, we show that β cells are also present in the extra-hepatic bile ducts of mice...

... for correspondence (e-mail: o.v.gerasimenko@liv.ac.uk ) 29 9 2005 © The Company of Biologists Limited 2006 2006 Ca 2+ stores Ryanodine Pancreas Two-photon Secretory granules Neurotransmitter- or hormone-elicited Ca 2+ release from intracellular stores into the cytosol...

... in the brain participate in paracrine signalling in the pancreas. Although the presence and releasability of GABA is well established in a number of different neuroendocrine cells, other neuroactive amino acids might serve similar paracrine functions as well. Our results with glycine specific antibodies show...

...Jonathan M. van Eyll; Christophe E. Pierreux; Frédéric P. Lemaigre; Guy G. Rousseau The pancreas develops from the endoderm to give rise to ducts, acini and islets of Langerhans. This process involves extracellular signals of the Transforming Growth Factor β (TGFβ) family. The aim of this work...

... acinar cells have greatly reduced levels of connexin32 protein. (A,B) Adult pancreas sections from wild-type (WT) and Mist1 KO mice were processed for Cx32 immunofluorescence(green). WT pancreas sections (A) show a high number of Cx32-containing gap junction plaques (arrows) whereas Mist1 KO...

... ). Myosin heavy chain turnover in cultured neonatal rat heart cells: effects of [Ca 2+ ]i and contractile activity. Am. J. Physiol. 271 , C01447 -C01456. Curry, D. L., Bennett, L. L. and Grodsky, G. M. ( 1968 ). Dynamics of insulin secretion by the perfused rat pancreas. Endocrinology 83 , 572...

... sulfated glycoproteins,including the zymogen granule structural component Muclin. I tested the hypothesis that sulfation and the O-linked glycosylation to which the sulfates are attached are required for normal formation of zymogen granules in the exocrine pancreas. Post-translational processing...

...Fang-Xu Jiang; Edouard G. Stanley; L. Jorge Gonez; Leonard C. Harrison Extracellular signals that guide pancreas cell development are not well characterized. In an in vitro culture system of dissociated pancreas cells from the E15.5 mouse fetus we show that, in the presence of the extracellular...

... for CF, it is essential to work on human tissue. We have established a tissue culture system for epithelial cells derived from normal mid-trimester foetal pancreas. The system as described below results in the establishment of primary cultures of epithelial cells from about 80% of pancreases (a total...