... signalling defects and suggest that they are responsible for insulin resistance, their cause–effect has been debated. Here, we find that the saturated fat palmitate (PA) causes insulin resistance owing to failure of GLUT4 translocation in skeletal muscle myoblasts and myotubes without impairing signalling...

... excitatory synapse formation in vitro and in vivo through motifs at its C-terminal domain. Hippocampus Lipid Palmitate Palmitoyl acyltransferase Palmitoylation Synapse Palmitoylation is a reversible post-translational lipid modification that anchors proteins to specialized membrane...

.... , Gordon J. I. , Banaszak L. J. (1989). Crystal structure of rat intestinal fatty-acid-binding protein. Refinement and analysis of the Escherichia coli-derived protein with bound palmitate . J. Mol. Biol. 208 , 327 - 339 . Shen R. , Lin C. T. , Bowman E. J. , Bowman B...

... in INS-1E cells, FACS-purified primary β-cells and human islets exposed to oleate and/or palmitate. Treatment with saturated and/or unsaturated FFA led to differential ER stress signaling. Palmitate induced more apoptosis and markedly activated the IRE1, PERK and ATF6 pathways, owing to a sustained...

...Maurine E. Linder; Robert J. Deschenes The acylation of proteins with palmitate and related fatty acids has been known for over 30 years, but the molecular machinery that carries out palmitoylation has only recently emerged from studies in the model organisms Saccharomyces cerevisiae and Drosophila...