... that is disfavoured at endogenous plasma membrane densities. Cytokine receptor Dimerization IL-4 IL-13 IL-4Rα IL-13Rα1 IL-2Rγ JAK3 Pak1 Pak2 Rac1 Endocytosis has traditionally been associated with the clearance of active receptors from the plasma membrane and hence signal downregulation...

... to Fas-related signals, the ubiquitously expressed p21-activated kinase 2 (Pak2) can be activated via cleavage by caspases to release a constitutively active C-terminal fragment, which mediates cell death. Our data show that huntingtin interacts with Pak2. Overexpression of huntingtin significantly...