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Keywords: Pak1
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Journal Articles
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Adhesion
J Cell Sci (2021) 134 (6): jcs254359.
Published: 29 March 2021
... on collagen. The activation of PAK1, a downstream effector of Cdc42, was required for vimentin phosphorylation and filament maturation. We propose that vimentin tunes cell migration through collagen by acting as an adaptor protein for focal adhesion proteins, thereby regulating β1 integrin activation...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2015) 128 (20): 3781–3795.
Published: 15 October 2015
... that is disfavoured at endogenous plasma membrane densities. Cytokine receptor Dimerization IL-4 IL-13 IL-4Rα IL-13Rα1 IL-2Rγ JAK3 Pak1 Pak2 Rac1 Endocytosis has traditionally been associated with the clearance of active receptors from the plasma membrane and hence signal downregulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (16): 3697–3712.
Published: 15 August 2013
... glomerular mesangial cells (MC) to mechanical stretch. MC produce extracellular matrix and profibrotic cytokines, including connective tissue growth factor (CTGF) when stretched. We show that p21-activated kinase 1 (Pak1) is activated by stretch in MC in culture and in vivo in a process marked by elevated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (22): 3729–3736.
Published: 15 November 2008
...Stephen D. Smith; Zahara M. Jaffer; Jonathan Chernoff; Anne J. Ridley PAK1 is a member of the p21-activated kinase (PAK) family of serine/threonine kinases that are activated by the Rho GTPases Rac and Cdc42, and are implicated in regulating morphological polarity, cell migration and adhesion. Here...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (20): 3700–3712.
Published: 15 October 2007
... the stroma can influence tumor behavior by regulating the tissue phenotype, we explored the role of extracellular matrix signaling and tissue organization in epithelial survival. We report that elevated (α6)β4 integrin-dependent Rac-Pak1 signaling supports resistance to apoptosis in mammary acini...
Includes: Supplementary data