... level. Intracellular Ca 2+ ([Ca 2+ ] i ) oscillations in interstitial cells of Cajal (ICCs; identified with c-Kit immunoreactivity) are considered to be the primary mechanism for the pacemaker activity in gastrointestinal motility. In the present study, RT-PCR examinations revealed predominant...

...) are considered to be the primary pacemaker activity in the gut. Here, we show evidence that periodic Ca 2+ release from intracellular Ca 2+ stores produces [Ca 2+ ] i oscillations in ICCs, using cell cluster preparations isolated from mouse ileum. The pacemaker [Ca 2+ ] i oscillations in ICCs are preserved...

...Michael Carroll; Mark Levasseur; Chris Wood; Michael Whitaker; Keith T. Jones; Alex McDougall In ascidians, as in mammals, sperm trigger repetitive Ca 2+ -waves that originate from cortical pacemakers situated in the vegetal hemisphere of the zygotes. In ascidians, a vegetal protrusion termed...

...Rémi Dumollard; Christian Sardet Calcium wave pacemakers in fertilized eggs of ascidians and mouse are associated with accumulations of cortical endoplasmic reticulum in the vegetal hemisphere. In ascidians, two distinct pacemakers (PM1 and PM2) generate two series of calcium waves necessary...